毒物兴奋效应作为一种可信剂量反应模型的成熟过程。
The maturing of hormesis as a credible dose-response model.
作者信息
Calabrese Edward J
机构信息
Environmental Health Sciences, School of Public Health, University of Massachusetts, Amherst, MA.
出版信息
Nonlinearity Biol Toxicol Med. 2003 Jul;1(3):319-43. doi: 10.1080/15401420390249934.
Abstract
Hormesis is a dose-response phenomenon that has received little recognition, credibility and acceptance as evidenced by its absence from major toxicological/risk assessment texts, governmental regulatory dose-response modeling for risk assessment, and non-visibility in major professional toxicological society national meetings. This paper traces the historical evolution of the hormetic dose-response hypothesis, why this model is not only credible but also more common than the widely accepted threshold model in direct comparative evaluation, and how the toxicological community made a critical error in rejecting hormesis, a rejection sustained over 70 years.
摘要
兴奋效应是一种剂量反应现象，却很少得到认可、可信度及接受度，这从主要毒理学/风险评估文本、政府监管风险评估的剂量反应模型中没有提及，以及在主要专业毒理学协会的全国会议上未被关注就可得到证明。本文追溯了兴奋效应剂量反应假说的历史演变，为何在直接比较评估中该模型不仅可信，而且比广泛接受的阈值模型更为常见，以及毒理学界在拒绝兴奋效应时是如何犯下关键错误的，这种拒绝持续了70多年。
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