Van der Lei B, Stronck J W, Wildevuur C R
Department of Surgery, University Hospital Groningen, The Netherlands.
Br J Plast Surg. 1991 Aug-Sep;44(6):428-33. doi: 10.1016/0007-1226(91)90201-t.
Polytetrafluoroethylene (PTFE) microvascular prostheses with a fibril length of 30 microns were pretreated with alcohol (n = 18), implanted into the abdominal aorta of rats and were evaluated at 1 day (n = 3), 1 week (n = 3), 3 weeks (n = 6) and 6 weeks (n = 6) to determine whether alcohol-pretreatment might improve their healing. Untreated PTFE microvascular prostheses (n = 18) functioned as controls (all prostheses: length 10 mm, I.D. 1.5 mm). The alcohol-pretreated PTFE microarterial prostheses were initially completely filled and covered with clot and showed fast and complete healing within 6 weeks: endothelial cells and smooth muscle cells on the luminal surface, and the interstices filled with fibrous-like tissue. In contrast, the untreated PTFE prostheses were initially not filled or covered with clot and showed only healing near the anastomotic sites and scarce tissue ingrowth into the wall. These results demonstrate that alcohol-pretreatment improves the healing characteristics of PTFE microarterial prostheses with a fibril length of 30 microns. The alcohol-pretreatment renders the PTFE material more accessible to clot and subsequently to cells.
将原纤维长度为30微米的聚四氟乙烯（PTFE）微血管假体用酒精预处理（n = 18），植入大鼠腹主动脉，并在1天（n = 3）、1周（n = 3）、3周（n = 6）和6周（n = 6）时进行评估，以确定酒精预处理是否能改善其愈合情况。未处理的PTFE微血管假体（n = 18）作为对照（所有假体：长度10毫米，内径1.5毫米）。酒精预处理的PTFE微动脉假体最初完全被血栓填充和覆盖，并在6周内显示出快速且完全的愈合：管腔表面有内皮细胞和平滑肌细胞，间隙充满纤维样组织。相比之下，未处理的PTFE假体最初未被血栓填充或覆盖，仅在吻合部位附近显示愈合，且很少有组织长入管壁。这些结果表明，酒精预处理可改善原纤维长度为30微米的PTFE微动脉假体的愈合特性。酒精预处理使PTFE材料更容易与血栓结合，进而与细胞结合。
