Caruso R A, Fedele F, Finocchiaro G, Pizzi G, Nunnari M, Gitto G, Fabiano V, Parisi A, Venuti A
Dipartimento di Patologia Umana, Policlinico Universitario, Messina, Italy.
Anticancer Res. 2009 Jan;29(1):449-53.
Angiogenesis requires complex multistep signalling pathways and a high degree of spatial and temporal coordination among endothelial cells and pericytes. The two cell types exhibit numerous contacts in vivo and in vitro, including the occurrence of peg-socket junctions.
Ultrastructural findings in 9 cases of advanced gastric carcinomas were reviewed with special emphasis on endothelium/pericyte peg-socket junctions.
The incidence of peg-socket junctions was approximately 8% in 5 out of 9 cases. The remaining 4 cases showed a very low rate, including two cases in whom interactions were totally absent. Peg-socket junctions consisted of cytoplasmic projection from the pericyte protruding into the endothelial indentation. The endothelial cells interacting with pericytes showed ultrastructural signs of partial stabilization such as continuous endothelial lining, regularly constructed interendothelial junctions, more or less integrated pericytes, and multilayered basement membrane.
Our ultrastructural study confirms previous reports regarding pericyte/endothelial peg-socket interdigitations in murine and human granulation tissues and extends these findings to the microvasculature of human gastric carcinomas.
血管生成需要复杂的多步骤信号通路以及内皮细胞和平滑肌周细胞之间高度的空间和时间协调。这两种细胞类型在体内和体外均表现出大量接触，包括栓-窝连接的出现。
回顾了9例进展期胃癌的超微结构结果，特别关注内皮细胞/平滑肌周细胞栓-窝连接。
9例中的5例栓-窝连接发生率约为8%。其余4例发生率极低，其中2例完全没有相互作用。栓-窝连接由平滑肌周细胞的细胞质突起伸入内皮凹陷组成。与平滑肌周细胞相互作用的内皮细胞表现出部分稳定的超微结构特征，如连续的内皮衬里、规则构建的内皮间连接、或多或少整合的平滑肌周细胞以及多层基底膜。
我们的超微结构研究证实了先前关于小鼠和人类肉芽组织中平滑肌周细胞/内皮栓-窝交错的报道，并将这些发现扩展至人类胃癌的微血管系统。
