少突胶质前体细胞与神经血管单元在健康和疾病中的相互作用。

Department of Neurophysiology, Institute of Physiology, University of Tübingen, 72074 Tübingen, Germany.

Cells. 2022 Jun 17;11(12):1954. doi: 10.3390/cells11121954.

Oligodendrocyte precursor cells (OPCs) are mostly known for their capability to differentiate into oligodendrocytes and myelinate axons. However, they have been observed to frequently interact with cells of the neurovascular unit during development, homeostasis, and under pathological conditions. The functional consequences of these interactions are largely unclear, but are increasingly studied. Although OPCs appear to be a rather homogenous cell population in the central nervous system (CNS), they present with an enormous potential to adapt to their microenvironment. In this review, it is summarized what is known about the various roles of OPC-vascular interactions, and the circumstances under which they have been observed.

少突胶质前体细胞（OPC）主要因其分化为少突胶质细胞和髓鞘轴突的能力而闻名。然而，人们已经观察到它们在发育、稳态和病理条件下经常与神经血管单元的细胞相互作用。这些相互作用的功能后果在很大程度上尚不清楚，但越来越受到研究。尽管 OPC 在中枢神经系统（CNS）中似乎是一个相当同质的细胞群体，但它们具有巨大的潜力来适应其微环境。在这篇综述中，总结了已知的 OPC-血管相互作用的各种作用以及观察到它们的情况。