Nojiri Kazunori, Nagano Yasuhiko, Tanaka Kuniya, Matsuo Kenichi, Yamagishi Shigeru, Ota Mituyoshi, Fujii Shouichi, Kunisaki Chikara, Togo Shinji, Shimada Hiroshi
Yokohama City University Medical Centre, Gastroenterological Centre, Yokohama, Japan.
Anticancer Res. 2009 Feb;29(2):583-8.
To evaluate the validity of surgical therapy for colorectal liver metastases in the elderly patients.
Between 1992 and 2004, 401 patients were diagnosed as having liver metastases from colorectal cancer. These comprised 64 patients aged 75 years or older and 337 patients aged less than 75 years.
Two hundred and thirty-two patients (57.9%) underwent potentially curative hepatic resection. Postoperative complications occurred in 29.6% of the older patients and in 23.4% of the younger patients. Mortality was 0% in the older group and 0.5% in the younger group. The overall 5-year survival rates of the older and younger group were 33.2% and 47.9%, respectively (p < 0.01). The proportion of patients who died of other diseases was significantly higher in the older (11.1%) than the younger group (2.0%) (p = 0.04).
Age cannot be regarded as a medical contraindication for hepatic resection of colorectal liver metastases.
评估老年患者结直肠癌肝转移手术治疗的有效性。
1992年至2004年间，401例患者被诊断为结直肠癌肝转移。其中64例患者年龄在75岁及以上，337例患者年龄小于75岁。
232例患者（57.9%）接受了潜在根治性肝切除术。老年患者术后并发症发生率为29.6%，年轻患者为23.4%。老年组死亡率为0%，年轻组为0.5%。老年组和年轻组的总体5年生存率分别为33.2%和47.9%（p<0.01）。老年组死于其他疾病的患者比例（11.1%）显著高于年轻组（2.0%）（p = 0.04）。
年龄不能被视为结直肠癌肝转移肝切除的医学禁忌证。
