老年患者（75岁及以上）结直肠癌肝转移灶肝切除的有效性

Validity of hepatic resection of colorectal liver metastases in the elderly (75 years and older).

作者信息

Nojiri Kazunori, Nagano Yasuhiko, Tanaka Kuniya, Matsuo Kenichi, Yamagishi Shigeru, Ota Mituyoshi, Fujii Shouichi, Kunisaki Chikara, Togo Shinji, Shimada Hiroshi

机构信息

Yokohama City University Medical Centre, Gastroenterological Centre, Yokohama, Japan.

出版信息

Anticancer Res. 2009 Feb;29(2):583-8.

PMID:19331207

Abstract

AIM

To evaluate the validity of surgical therapy for colorectal liver metastases in the elderly patients.

PATIENTS AND METHODS

Between 1992 and 2004, 401 patients were diagnosed as having liver metastases from colorectal cancer. These comprised 64 patients aged 75 years or older and 337 patients aged less than 75 years.

RESULTS

Two hundred and thirty-two patients (57.9%) underwent potentially curative hepatic resection. Postoperative complications occurred in 29.6% of the older patients and in 23.4% of the younger patients. Mortality was 0% in the older group and 0.5% in the younger group. The overall 5-year survival rates of the older and younger group were 33.2% and 47.9%, respectively (p < 0.01). The proportion of patients who died of other diseases was significantly higher in the older (11.1%) than the younger group (2.0%) (p = 0.04).

CONCLUSION

Age cannot be regarded as a medical contraindication for hepatic resection of colorectal liver metastases.

摘要

目的

评估老年患者结直肠癌肝转移手术治疗的有效性。

患者与方法

1992年至2004年间，401例患者被诊断为结直肠癌肝转移。其中64例患者年龄在75岁及以上，337例患者年龄小于75岁。

结果

232例患者（57.9%）接受了潜在根治性肝切除术。老年患者术后并发症发生率为29.6%，年轻患者为23.4%。老年组死亡率为0%，年轻组为0.5%。老年组和年轻组的总体5年生存率分别为33.2%和47.9%（p<0.01）。老年组死于其他疾病的患者比例（11.1%）显著高于年轻组（2.0%）（p = 0.04）。