Hsu Nan-Yung, Wang Hwei-Chung, Wang Chung-Hsing, Chiu Chang-Fang, Tseng Hsien-Chang, Liang Shiu-Yun, Tsai Chia-Wen, Lin Cheng-Chieh, Bau Da-Tian
Department of Chest Surgery, China Medical University Hospital, Taichung, Taiwan, ROC.
Anticancer Res. 2009 Feb;29(2):725-30.
To evaluate the association between the polymorphisms of the Exo1 gene and the risk of lung cancer in central Taiwan.
In this hospital-based study, the association of Exol A-1419G (rs3754093), C-908G (rs10802996), A238G (rs1776177), C498T (rs1635517), K589E (rs1047840), G670E (rs1776148), C723R (rs1635498), L757P (rs9350) and C3114T (rs851797) polymorphisms with lung cancer risk in a central Taiwanese population was investigated. In total, 358 patients with lung cancer and 358 age- and gender-matched healthy controls recruited from the China Medical Hospital in central Taiwan were genotyped.
A significantly different distribution was found in the frequency of the Exo1 K589E genotype, but not the other genotypes, between the lung cancer and control groups. The A allele Exo1 K589E conferred a significantly (p = 0.0097) increased risk of lung cancer. As for the rest of the polymorphisms, there was no difference in distribution between the lung cancer and control groups. Gene environment interactions with smoking were significant for Exo1 K589E polymorphism. The Exo1 K589E AG and AA genotype in association with smoking conferred an increased risk of 1.7208 (95% confidence interval = 1.2188-2.4295) for lung cancer.
Our results provide the first evidence that the A allele of Exo1 K589E may be associated with the development of lung cancer and may be a novel useful marker for primary prevention and anticancer intervention.
评估台湾中部地区Exo1基因多态性与肺癌风险之间的关联。
在这项基于医院的研究中，调查了台湾中部地区人群中Exo1基因A-1419G（rs3754093）、C-908G（rs10802996）、A238G（rs1776177）、C498T（rs1635517）、K589E（rs1047840）、G670E（rs1776148）、C723R（rs1635498）、L757P（rs9350）和C3114T（rs851797）多态性与肺癌风险的关联。总共对从台湾中部中国医药大学医院招募的358例肺癌患者和358例年龄及性别匹配的健康对照进行了基因分型。
肺癌组与对照组之间，Exo1基因K589E基因型的频率分布存在显著差异，而其他基因型无此差异。Exo1基因K589E的A等位基因使肺癌风险显著增加（p = 0.0097）。至于其余的多态性，肺癌组与对照组之间的分布无差异。Exo1基因K589E多态性与吸烟的基因环境相互作用显著。Exo1基因K589E的AG和AA基因型与吸烟相关，使肺癌风险增加1.7208倍（95%置信区间 = 1.2188 - 2.4295）。
我们的研究结果首次证明，Exo1基因K589E的A等位基因可能与肺癌的发生有关，可能是初级预防和抗癌干预的一个新的有用标志物。
