Babu K Suresh, Roberts Fiona, Bryden Fiona, McCafferty Alasdair, Downer Penny, Hansell Douglas T, Jones Richard, Milroy Robert
Department of Respiratory Medicine, Stobhill Hospital, UK.
J Thorac Oncol. 2009 Apr;4(4):540-2. doi: 10.1097/JTO.0b013e31819c8556.
Metastatic disease to the breast from extra mammary sites is uncommon and has an incidence of 0.5 to 3%. It is important to make an accurate diagnosis as this has an impact on the therapeutic planning and management. Clinically, it can be difficult to differentiate between primary breast cancer and a metastatic disease. An incorrect diagnosis can lead to unnecessary surgical interventions. Immunohistochemistry has a significant role in identifying the primary origin of tumor and has to be considered in the presence of unusual cytologic patterns. We report three cases of metastatic disease to breast from primary lung tumors. The cases demonstrate the difficulties encountered in the diagnosis and the impact on the management of these patients.
乳腺外部位转移至乳腺的疾病并不常见,发病率为0.5%至3%。准确诊断很重要,因为这会影响治疗计划和管理。临床上,原发性乳腺癌和转移性疾病可能难以区分。错误的诊断可能导致不必要的手术干预。免疫组织化学在确定肿瘤的原发部位方面具有重要作用,在出现不寻常的细胞学模式时必须加以考虑。我们报告了3例原发性肺癌转移至乳腺的病例。这些病例展示了诊断中遇到的困难以及对这些患者管理的影响。