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经微囊藻天然水华提取物（含微囊藻毒素）预先暴露后，斑马鱼幼鱼诱导产生补偿性生长。

Compensatory growth induced in zebrafish larvae after pre-exposure to a Microcystis aeruginosa natural bloom extract containing microcystins.

机构信息

Department of Biology, Laboratory of Biology and Biotechnology of Microorganisms, Microbiology and Environmental Toxicology Unit, Faculty of Sciences Semlalia Marrakech, University Cadi Ayyad, P.O. Box 2390, Marrakech 40000, Morocco.

Centro Interdisciplinar de Investigação Marinha e Ambiental, CIIMAR/CIMAR-LA, Rua dos Bragas 289, Porto 4050-123, Portugal.

出版信息

Int J Mol Sci. 2009 Jan;10(1):133-146. doi: 10.3390/ijms10010133. Epub 2009 Jan 5.

DOI:10.3390/ijms10010133
PMID:19333438
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2662464/
Abstract

Early life stage tests with zebrafish (Danio rerio) were used to detect toxic effects of compounds from a Microcystis aeruginosa natural bloom extract on their embryolarval development. We carried out the exposure of developing stages of fish to complex cyanobacterial blooms containing hepatotoxic molecules - microcystins. Fish embryo tests performed with the bloom extract containing 3 mg.L(-1) Eq microcystin-LR showed that after 24 h of exposure all fish embryos died. The same tests performed with other diluted extracts (containing 0.3, 0.1 and 0.03 mg.L(-1) Eq microcystin-LR) were shown to have an influence on zebrafish development and a large number of embryos showed malformation signs (edema, bent and curving tail). After hatching the larvae were transferred to a medium without toxins to follow the larval development under the new conditions. The specific growth of the pre-exposed larvae was significantly more important than that of the control larvae. This may represent a compensatory growth used to reduce the difference in size with the control fish noted after hatching.

摘要

采用斑马鱼（Danio rerio）早期生活阶段测试来检测来自铜绿微囊藻天然水华提取物的化合物对其胚胎幼体发育的毒性影响。我们对含有肝毒性分子 - 微囊藻毒素的复杂蓝藻水华进行了鱼类发育阶段的暴露。用含有 3 mg.L(-1) Eq 微囊藻毒素-LR 的水华提取物进行的鱼胚胎测试表明，暴露 24 小时后所有鱼胚胎均死亡。用其他稀释提取物（含有 0.3、0.1 和 0.03 mg.L(-1) Eq 微囊藻毒素-LR）进行的相同测试表明对斑马鱼发育有影响，大量胚胎出现畸形迹象（水肿，弯曲和弯曲的尾巴）。孵化后，幼虫被转移到没有毒素的培养基中，以在新条件下观察幼虫发育。预先暴露的幼虫的特定生长速度明显高于对照幼虫。这可能代表了一种补偿性生长，用于减少孵化后与对照鱼之间大小差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be0e/2662464/3abea3388130/ijms-10-00133f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be0e/2662464/331a66bc832d/ijms-10-00133f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be0e/2662464/ad9f789fc64b/ijms-10-00133f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be0e/2662464/9ff2b7a1c2e0/ijms-10-00133f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be0e/2662464/367fca47253d/ijms-10-00133f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be0e/2662464/3abea3388130/ijms-10-00133f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be0e/2662464/331a66bc832d/ijms-10-00133f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be0e/2662464/ad9f789fc64b/ijms-10-00133f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be0e/2662464/9ff2b7a1c2e0/ijms-10-00133f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be0e/2662464/367fca47253d/ijms-10-00133f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be0e/2662464/3abea3388130/ijms-10-00133f5.jpg

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