Gugjoo M B, Sharma G T, Aithal H P, Kinjavdekar P
Division of Surgery, Modular Laboratory Building, Indian Veterinary Research Institute, Izatnagar; Clinical Veterinary Services Complex, Faculty of Veterinary Sciences & Animal Husbandry, Shuhama, Sher-e-Kashmir University of Agricultural Sciences & Technology, Srinagar, India.
Division of Surgery, Modular Laboratory Building, Indian Veterinary Research Institute, Izatnagar, India.
Indian J Med Res. 2016 Sep;144(3):339-347. doi: 10.4103/0971-5916.198724.
Articular cartilage injury poses a major challenge for both the patient and orthopaedician. Articular cartilage defects once formed do not regenerate spontaneously, rather replaced by fibrocartilage which is weaker in mechanical competence than the normal hyaline cartilage. Mesenchymal stem cells (MSCs) along with different growth factors and scaffolds are currently incorporated in tissue engineering to overcome the deficiencies associated with currently available surgical methods and to facilitate cartilage healing. MSCs, being readily available with a potential to differentiate into chondrocytes which are enhanced by the application of different growth factors, are considered for effective repair of articular cartilage after injury. However, therapeutic application of MSCs and growth factors for cartilage repair remains in its infancy, with no comparative clinical study to that of the other surgical techniques. The present review covers the role of MSCs, growth factors and scaffolds for the repair of articular cartilage injury.
关节软骨损伤对患者和骨科医生来说都是一项重大挑战。关节软骨缺损一旦形成便不会自发再生，而是会被纤维软骨替代，纤维软骨的机械性能比正常透明软骨弱。目前，间充质干细胞（MSCs）以及不同的生长因子和支架被应用于组织工程，以克服现有手术方法的不足并促进软骨愈合。MSCs易于获取，具有分化为软骨细胞的潜力，且不同生长因子的应用可增强这种潜力，因此被认为可有效修复损伤后的关节软骨。然而，MSCs和生长因子在软骨修复中的治疗应用仍处于起步阶段，尚无与其他手术技术的对比临床研究。本综述涵盖了MSCs、生长因子和支架在关节软骨损伤修复中的作用。
