Martin David D, Deusch Dorothee, Schweizer Roland, Binder Gerhard, Thodberg Hans Henrik, Ranke Michael B
Paediatric Endocrinology Section, University Children's Hospital, Tuebingen, Germany.
Pediatr Radiol. 2009 Jun;39(6):598-607. doi: 10.1007/s00247-008-1114-4. Epub 2009 Mar 31.
Bone age (BA) rating is time consuming and highly rater dependent.
To adjust the fully automated BoneXpert method to agree with the manual Greulich and Pyle BA (GP BA) ratings of five raters and to validate the accuracy for short children.
A total of 1,097 left hand radiographs from 188 children with short stature, including growth hormone deficiency (44%) and Turner syndrome (29%) were evaluated.
BoneXpert rejected 14 of the 1,097 radiographs, and deviated by more than 1.9 years from the operator BA for 27 radiographs. These were rerated blindly by four operators. Of the 27 new ratings, 26 were within 1.9 years of the automatic BA values. The root mean square deviation between manual and automatic rating was 0.72 years (95% CI 0.69-0.75).
BoneXpert's ability to process 99% of images automatically without errors, and to obtain good agreement with an operator suggests that the method is efficient and reliable for short children.
骨龄（BA）评定耗时且高度依赖评定者。
调整全自动BoneXpert方法，使其与五位评定者的手动格鲁利希和派尔骨龄（GP BA）评定结果一致，并验证该方法对身材矮小儿童的准确性。
对188名身材矮小儿童的1097张左手X光片进行了评估，这些儿童包括生长激素缺乏症（44%）和特纳综合征（29%）。
BoneXpert拒绝了1097张X光片中的14张，27张X光片的骨龄与操作者评定结果相差超过1.9岁。这27张X光片由四位操作者进行了重新评定。在27个新的评定结果中，26个在自动骨龄值的1.9岁范围内。手动评定与自动评定之间的均方根偏差为0.72岁（95%可信区间0.69 - 0.75）。
BoneXpert能够自动无误地处理99%的图像，并与操作者取得良好的一致性，这表明该方法对身材矮小儿童高效且可靠。
