Paz C, Gutiérrez-Baeza F, Bazán-Perkins B
Unit of Brain Research, Instituto Nacional de Neurología y Neurocirugía, México, Mexico.
Brain Res. 1991 Aug 30;558(1):90-2. doi: 10.1016/0006-8993(91)90718-b.
We studied the effect of transections at the superior cerebellar peduncle during the evolution of amygdaloid kindling. Dentato- and interposito-thalamic pathways, including the ascending fastigial fibers, were transected in 10 rats at the contralateral side of the stimulated amygdala, and in other 8 at the ipsilateral side. A group of 18 rats was used as control. Contralateral lesion significantly slowed amygdala kindling, while ipsilateral lesion decreased kindled seizure duration. Furthermore, when kindled seizures were reached by 6 control rats, transection of the ipsilateral superior cerebellar peduncle led to reduction of subsequent seizures. These specific effects produced by transection of the superior cerebellar peduncle suggest that the cerebellum could exert a tonic effect over the participating circuitry used by the kindling process.
我们研究了在杏仁核点燃过程中，小脑上脚横断的影响。在10只大鼠中，于受刺激杏仁核的对侧横断齿状核-丘脑和间位核-丘脑通路，包括上行的顶核纤维，另外8只大鼠在同侧横断。一组18只大鼠作为对照。对侧损伤显著减缓了杏仁核点燃，而同侧损伤缩短了点燃性癫痫发作的持续时间。此外，当6只对照大鼠达到点燃性癫痫发作时，横断同侧小脑上脚导致后续癫痫发作减少。小脑上脚横断所产生的这些特定效应表明，小脑可能对点燃过程中所使用的参与性神经回路发挥着紧张性作用。
