Kasarskis E J, Schuna A
Am J Clin Nutr. 1980 Dec;33(12):2609-12. doi: 10.1093/ajcn/33.12.2609.
The response of serum alkaline phosphatase (AP) during the first 2 weeks of zinc (Zn) replacement therapy was studied retrospectively in three Zn-deficient adults. The ratio of the maximal posttreatment to pretreatment serum AP level (AP ratio) correlated inversely with pretreatment serum Zn level. A similar linear relationship was apparent when the AP ratio was calculated from published cases of Zn deficiency of diverse etiologies. Serial determinations of serum AP and calculation of the AP ratio during a trial of Zn therapy may provide biochemical confirmation of the adequacy of Zn replacement and could potentially be useful in detection of subclinical Zn deficiency.
对三名锌缺乏的成年人进行了回顾性研究，观察了锌替代疗法开始后前两周血清碱性磷酸酶（AP）的反应。治疗后血清AP水平与治疗前血清AP水平的比值（AP比值）与治疗前血清锌水平呈负相关。当从不同病因的锌缺乏已发表病例中计算AP比值时，也呈现出类似的线性关系。在锌治疗试验期间连续测定血清AP并计算AP比值，可能为锌替代是否充足提供生化依据，并且可能有助于检测亚临床锌缺乏。
