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脐血移植：最新进展

Cord blood transplantation: state of the art.

作者信息

Gluckman Eliane, Rocha Vanderson

机构信息

Eurocord APHP and University Paris VII, Hospital Saint Louis, Paris, France.

出版信息

Haematologica. 2009 Apr;94(4):451-4. doi: 10.3324/haematol.2009.005694.

DOI:10.3324/haematol.2009.005694
PMID:19336748
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2663606/
Abstract

Cord blood is an unlimited source of hematopoietic stem cells for allogeneic hematopoietic stem cell transplant. In this perspective article, Drs. Gluckman and Rocha examine the current status and the new challenges of cord blood transplant. See related article on page 536.

摘要

脐血是异基因造血干细胞移植中造血干细胞的无限来源。在这篇观点文章中，格鲁克曼博士和罗查博士探讨了脐血移植的现状和新挑战。见第536页的相关文章。

相似文献

1
Cord blood transplantation: state of the art.脐血移植：最新进展
Haematologica. 2009 Apr;94(4):451-4. doi: 10.3324/haematol.2009.005694.
2
Multipotential cord blood cells. Are they the future?
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3
[Stem cell transplantation of umbilical chord blood from related and non-related donors in children and adults--a review of stem cell transplantation from umbilical cord blood].[儿童及成人亲属与非亲属供者脐带血干细胞移植——脐带血干细胞移植综述]
Z Geburtshilfe Neonatol. 2005 Oct;209(5):159-66. doi: 10.1055/s-2005-873142.
4
Update on umbilical cord blood transplantation.脐带血移植的最新进展。
Curr Opin Pediatr. 2009 Feb;21(1):22-9. doi: 10.1097/mop.0b013e32832130bc.
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Umbilical cord blood and type 1 diabetes: A road ahead or dead end?脐带血与1型糖尿病：前行之路还是死胡同？
Diabetes Care. 2009 Nov;32(11):2138-9. doi: 10.2337/dc09-1456.
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Cellular therapies: a Canadian blood services research and development symposium.
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Umbilical cord stem cell transplantation.脐带干细胞移植
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Symposium summary.
Biol Blood Marrow Transplant. 2005 Nov;11(11):921-7. doi: 10.1016/j.bbmt.2005.08.028.
9
Cord blood banking and transplantation in 2010.2010年的脐血库与移植
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引用本文的文献

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Romiplostim versus Recombinant human thrombopoietin in umbilical cord blood transplantation: a single-center retrospective study.罗米司亭与重组人血小板生成素在脐带血移植中的比较：一项单中心回顾性研究。
Ann Hematol. 2025 Jul 9. doi: 10.1007/s00277-025-06490-z.
2
Safety of romiplostim administered immediately after cord-blood transplantation: a phase 1 trial.罗米司亭在脐带血移植后立即给药的安全性：一项 1 期试验。
Ann Hematol. 2023 Oct;102(10):2895-2902. doi: 10.1007/s00277-023-05410-3. Epub 2023 Aug 17.
3
Cord Blood Plasma and Placental Mesenchymal Stem Cells-Derived Exosomes Increase Ex Vivo Expansion of Human Cord Blood Hematopoietic Stem Cells While Maintaining Their Stemness.脐带血血浆和胎盘间充质干细胞衍生的外泌体在维持人脐带血造血干/祖细胞干性的同时增加其体外扩增。
Cells. 2023 Jan 7;12(2):250. doi: 10.3390/cells12020250.
4
Therapeutic Perspectives for the Clinical Application of Umbilical Cord Hematopoietic and Mesenchymal Stem Cells: Overcoming Complications Arising After Allogeneic Hematopoietic Stem Cell Transplantation.脐带血造血和间充质干细胞的临床应用治疗展望：克服异基因造血干细胞移植后的并发症。
Adv Exp Med Biol. 2023;1409:111-126. doi: 10.1007/5584_2022_726.
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Umbilical cord blood transplants facilitated by the French cord blood banks network. On behalf of the Agency of Biomedicine, Eurocord and the French society of bone marrow transplant and cell therapy (SFGM-TC).法国脐带血库网络促成的脐带血移植。代表机构为生物医学署、欧洲脐带血组织和法国骨髓移植与细胞治疗学会（SFGM-TC）。
Bone Marrow Transplant. 2021 Oct;56(10):2497-2509. doi: 10.1038/s41409-021-01313-x. Epub 2021 May 14.
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The Bioactive Peptide SL-13R Expands Human Umbilical Cord Blood Hematopoietic Stem and Progenitor Cells In Vitro.SL-13R 生物活性肽在体外扩增人脐血造血干/祖细胞。
Molecules. 2021 Apr 1;26(7):1995. doi: 10.3390/molecules26071995.
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Likelihood of Proceeding to Allogeneic Hematopoietic Cell Transplantation in the United States after Search Activation in the National Registry: Impact of Patient Age, Disease, and Search Prognosis.在美国国家登记处搜索激活后进行异基因造血细胞移植的可能性：患者年龄、疾病和搜索预后的影响。
Transplant Cell Ther. 2021 Feb;27(2):184.e1-184.e13. doi: 10.1016/j.bbmt.2020.10.004. Epub 2020 Oct 10.
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The influence of stem cell source on transplant outcomes for pediatric patients with acute myeloid leukemia.干细胞来源对小儿急性髓系白血病患者移植结局的影响。
Blood Adv. 2019 Apr 9;3(7):1118-1128. doi: 10.1182/bloodadvances.2018025908.
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Ex Vivo Expansion of Hematopoietic Stem and Progenitor Cells from Umbilical Cord Blood.脐血造血干细胞和祖细胞的体外扩增
Acta Naturae. 2016 Jul-Sep;8(3):6-16.
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Multiple allogeneic progenitors in combination function as a unit to support early transient hematopoiesis in transplantation.多种同种异体祖细胞联合发挥作用，作为一个整体支持移植中的早期短暂造血。
J Exp Med. 2016 Aug 22;213(9):1865-80. doi: 10.1084/jem.20151493. Epub 2016 Aug 8.

本文引用的文献

1
Cord blood stem cells for hematopoietic stem cell transplantation in the UK: how big should the bank be?英国用于造血干细胞移植的脐血干细胞：库的规模应该有多大？
Haematologica. 2009 Apr;94(4):536-41. doi: 10.3324/haematol.2008.002741. Epub 2009 Feb 19.
2
Use of cost-effectiveness analysis to determine inventory size for a national cord blood bank.
Med Decis Making. 2008 Mar-Apr;28(2):243-53. doi: 10.1177/0272989X07308750. Epub 2008 Mar 18.
3
State of the art review: HLA matching and outcome of unrelated donor umbilical cord blood transplants.前沿综述：人类白细胞抗原匹配与无关供者脐血移植的结果
Biol Blood Marrow Transplant. 2008 Jan;14(1):1-6. doi: 10.1016/j.bbmt.2007.11.003.
4
Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukaemia: a comparison study.无关供者脐血与骨髓移植治疗儿童急性白血病的疗效：一项比较研究。
Lancet. 2007 Jun 9;369(9577):1947-54. doi: 10.1016/S0140-6736(07)60915-5.
5
A meta-analysis of unrelated donor umbilical cord blood transplantation versus unrelated donor bone marrow transplantation in adult and pediatric patients.成人和儿童患者中无关供者脐血移植与无关供者骨髓移植的荟萃分析。
Biol Blood Marrow Transplant. 2007 Apr;13(4):444-53. doi: 10.1016/j.bbmt.2006.11.005. Epub 2007 Feb 15.
6
Comparative single-institute analysis of cord blood transplantation from unrelated donors with bone marrow or peripheral blood stem-cell transplants from related donors in adult patients with hematologic malignancies after myeloablative conditioning regimen.清髓性预处理方案后，对成年血液系统恶性肿瘤患者进行无关供者脐血移植与相关供者骨髓或外周血干细胞移植的单机构比较分析。
Blood. 2007 Feb 1;109(3):1322-30. doi: 10.1182/blood-2006-04-020172. Epub 2006 Oct 12.
7
Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia.成人急性白血病患者接受来自无关供者的脐带血或骨髓移植。
N Engl J Med. 2004 Nov 25;351(22):2276-85. doi: 10.1056/NEJMoa041469.
8
Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia.成年白血病患者接受无关供者脐血或骨髓移植后的结局。
N Engl J Med. 2004 Nov 25;351(22):2265-75. doi: 10.1056/NEJMoa041276.
9
Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy.移植两个部分人类白细胞抗原（HLA）匹配的脐带血单位以提高血液系统恶性肿瘤成年患者的植入率。
Blood. 2005 Feb 1;105(3):1343-7. doi: 10.1182/blood-2004-07-2717. Epub 2004 Oct 5.
10
Factors associated with outcomes of unrelated cord blood transplant: guidelines for donor choice.非亲缘脐血移植结局的相关因素：供者选择指南
Exp Hematol. 2004 Apr;32(4):397-407. doi: 10.1016/j.exphem.2004.01.002.