慢性退行性神经疾病中的免疫系统反应。

Reactions of the immune system in chronic degenerative neurological diseases.

作者信息

McGeer P L, McGeer E G, Kawamata T, Yamada T, Akiyama H

机构信息

Kinsmen Laboratory of Neurological Research, Department of Psychiatry, University of British Columbia, Vancouver, Canada.

出版信息

Can J Neurol Sci. 1991 Aug;18(3 Suppl):376-9. doi: 10.1017/s0317167100032479.

DOI:10.1017/s0317167100032479

PMID:1933684

Abstract

Elements consistent with a cell mediated immune response were identified immunohistochemically in amyotrophic lateral sclerosis (ALS) spinal cord and Alzheimer disease (AD) hippocampus. T helper/inducer and cytotoxic/suppressor lymphocytes were detected in affected tissues in both diseases. In addition, abundant reactive microglia were found expressing the major histocompatibility glycoproteins HLA-A,B,C and HLA-DR, as well as receptors for the Fc chain (Fc gamma R1), for complement 3 and 4, and for vitronectin. In AD, the complement proteins C1q, C4d, C3d and C5b-9 were found on dystrophic neurites, neuropile threads and some neurofibrillary tangles. In ALS, the only complement proteins identified were C4d and C3d. The integrin ligands vitronectin and ICAM-1 were also identified in affected tissues in both diseases.

摘要

在肌萎缩侧索硬化症（ALS）脊髓和阿尔茨海默病（AD）海马体中，通过免疫组织化学方法鉴定出了与细胞介导的免疫反应一致的成分。在这两种疾病的受累组织中均检测到辅助性T/诱导性淋巴细胞以及细胞毒性/抑制性淋巴细胞。此外，还发现大量反应性小胶质细胞表达主要组织相容性糖蛋白HLA - A、B、C和HLA - DR，以及Fc链受体（FcγR1）、补体3和4受体以及玻连蛋白受体。在AD中，在营养不良的神经突、神经毡丝和一些神经原纤维缠结上发现了补体蛋白C1q、C4d、C3d和C5b - 9。在ALS中，鉴定出的唯一补体蛋白是C4d和C3d。在这两种疾病的受累组织中还鉴定出了整合素配体玻连蛋白和细胞间黏附分子 - 1（ICAM - 1）。