Hilgert Eva, Bergmann Christoph, Fichtner Alexander, Gires Olivier, Issing Wolfgang
Department of Otorhinolaryngology, Klinikum Grosshadern, Marchioninistrasse 15, Ludwig-Maximilians University, Munich, Germany.
Eur J Cancer Prev. 2009 Apr;18(2):120-6. doi: 10.1097/CEJ.0b013e32831012a4.
This study represents an in-depth evaluation of the impact of smoking and alcohol consumption on patients' outcome in 809 cases of oropharyngeal carcinoma. Prognostic parameters and additional information such as smoking and drinking habits were evaluated referring to the patients' case notes at the time point of first diagnosis. The overall 10-year survival rate was 45.5%, whereas 33.4% of the patients remained relapse-free. The great majority (92%) of patients had a history of smoking or were current smokers, whereas only 8% of the collective never smoked in their lifetime. Interestingly, we found a significant reduction of 10-year survival rates for smokers (28.8%) in comparison with nonsmokers (43.1%) and ex-smokers (P=0.0007). This study presents data from a large cohort of patients with oropharyngeal carcinoma providing evidence for a relationship between alcohol and tobacco consumption, and significantly worse prognosis.
本研究对809例口咽癌患者中吸烟和饮酒对患者预后的影响进行了深入评估。在首次诊断时，参考患者的病历评估了预后参数以及吸烟和饮酒习惯等附加信息。总体10年生存率为45.5%，而33.4%的患者无复发。绝大多数（92%）患者有吸烟史或为当前吸烟者，而只有8%的患者一生中从未吸烟。有趣的是，我们发现吸烟者的10年生存率（28.8%）与不吸烟者（43.1%）和已戒烟者相比显著降低（P=0.0007）。本研究展示了来自一大群口咽癌患者的数据，为酒精和烟草消费之间的关系以及显著更差的预后提供了证据。
