Milbrath Meghan O'Grady, Wenger Yvan, Chang Chiung-Wen, Emond Claude, Garabrant David, Gillespie Brenda W, Jolliet Olivier
Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan 48109-2029, USA.
Environ Health Perspect. 2009 Mar;117(3):417-25. doi: 10.1289/ehp.11781. Epub 2008 Oct 3.
In this study we reviewed the half-life data in the literature for the 29 dioxin, furan, and polychlorinated biphenyl congeners named in the World Health Organization toxic equivalency factor scheme, with the aim of providing a reference value for the half-life of each congener in the human body and a method of half-life estimation that accounts for an individual's personal characteristics.
We compared data from >30 studies containing congener-specific elimination rates. Half-life data were extracted and compiled into a summary table. We then created a subset of these data based on defined exclusionary criteria.
We defined values for each congener that approximate the half-life in an infant and in an adult. A linear interpolation of these values was used to examine the relationship between half-life and age, percent body fat, and absolute body fat. We developed predictive equations based on these relationships and adjustments for individual characteristics.
The half-life of dioxins in the body can be predicted using a linear relationship with age adjusted for body fat, smoking, and breast-feeding. Data suggest an alternative method based on a linear relationship between half-life and total body fat, but this approach requires further testing and validation with individual measurements.
在本研究中，我们回顾了世界卫生组织毒性当量因子方案中列出的29种二恶英、呋喃和多氯联苯同系物的文献半衰期数据，目的是为每种同系物在人体中的半衰期提供参考值，以及一种考虑个体特征的半衰期估算方法。
我们比较了30多项包含同系物特异性消除率的研究数据。提取半衰期数据并编制成汇总表。然后根据定义的排除标准创建这些数据的一个子集。
我们定义了每种同系物在婴儿和成人中的近似半衰期值。这些值的线性插值用于研究半衰期与年龄、体脂百分比和绝对体脂之间的关系。我们基于这些关系和个体特征调整开发了预测方程。
二恶英在体内的半衰期可以通过与根据体脂、吸烟和母乳喂养调整后的年龄的线性关系来预测。数据表明了一种基于半衰期与总体脂之间线性关系的替代方法，但这种方法需要通过个体测量进行进一步测试和验证。
