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在一只患有多个室间隔缺损的羔羊中使用替米考星的不良后果。

Adverse outcome of using tilmicosin in a lamb with multiple ventricular septal defects.

作者信息

Christodoulopoulos Georgios

机构信息

Clinic of Medicine, School of Veterinary Medicine, University of Thessaly, Karditsa, Greece.

出版信息

Can Vet J. 2009 Jan;50(1):61-3. doi: 10.4141/cjas70-008.

DOI:10.4141/cjas70-008
PMID:19337615
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2603654/
Abstract

A 15-day-old, 6.08 kg, lamb was injected subcutaneously with tilmicosin 15 mg/kg body weight. Approximately 15 min later, the lamb died. During necropsy, the heart was found to have multiple ventricular septal defects. Death was attributed to sudden heart failure due to the cardiac effects of tilmicosin in a heart having congenital defects.

摘要

一只15日龄、体重6.08千克的羔羊皮下注射了15毫克/千克体重的替米考星。大约15分钟后,羔羊死亡。尸检时发现心脏有多个室间隔缺损。死亡原因是在一只患有先天性心脏缺陷的羊身上,替米考星对心脏的影响导致突然心力衰竭。

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本文引用的文献

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The possible protective effect of L-carnitine on tilmicosin-induced cardiotoxicity in mice.左旋肉碱对替米考星诱导的小鼠心脏毒性的可能保护作用。
J Vet Med A Physiol Pathol Clin Med. 2007 Apr;54(3):144-6. doi: 10.1111/j.1439-0442.2007.00897.x.
2
Efficacy of difloxacin against respiratory infections of lambs.
J Vet Pharmacol Ther. 2005 Jun;28(3):325-8. doi: 10.1111/j.1365-2885.2005.00658.x.
3
Tilmicosin administration to young lambs with respiratory infection: safety and efficacy considerations.给患有呼吸道感染的幼龄羔羊使用替米考星:安全性和有效性考量。
J Vet Pharmacol Ther. 2002 Oct;25(5):393-7. doi: 10.1046/j.1365-2885.2002.00433.x.
4
The effect of tilmicosin administered to ewes prior to lambing on incidence of clinical mastitis and subsequent lamb performance.在产羔前给母羊施用替米考星对临床乳腺炎发病率及随后羔羊性能的影响。
Can Vet J. 2000 Apr;41(4):306-11.
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Pharmacokinetics and pharmacodynamics of tilmicosin in sheep and cattle.
J Vet Pharmacol Ther. 1998 Dec;21(6):444-52. doi: 10.1046/j.1365-2885.1998.00177.x.
6
Treatment of experimentally induced pneumonic pasteurellosis of young calves with tilmicosin.用替米考星治疗实验性诱发的犊牛肺炎型巴氏杆菌病。
Can J Vet Res. 1997 Jul;61(3):187-92.
7
Use of tilmicosin for treatment of pasteurellosis in rabbits.替米考星用于治疗兔巴氏杆菌病。
Am J Vet Res. 1996 Aug;57(8):1180-4.
8
Cardiovascular effects of the macrolide antibiotic tilmicosin, administered alone and in combination with propranolol or dobutamine, in conscious unrestrained dogs.在清醒自由活动犬中,单独给予以及与普萘洛尔或多巴酚丁胺联合给予大环内酯类抗生素替米考星的心血管效应。
J Vet Pharmacol Ther. 1996 Jun;19(3):225-32. doi: 10.1111/j.1365-2885.1996.tb00042.x.
9
A review of the toxicology of the antibiotic MICOTIL 300.抗生素米考星300的毒理学综述。
Vet Hum Toxicol. 1993 Apr;35(2):151-8.
10
Human exposures to tilmicosin (MICOTIL).人类接触替米考星(迈克替)的情况。
Vet Hum Toxicol. 1994 Aug;36(4):306-8.