Jordan W H, Byrd R A, Cochrane R L, Hanasono G K, Hoyt J A, Main B W, Meyerhoff R D, Sarazan R D
Lilly Research Laboratories, Greenfield, Indiana 46140.
Vet Hum Toxicol. 1993 Apr;35(2):151-8.
MICOTIL 300 is a new macrolide antibiotic for the treatment of Bovine Respiratory Disease complex. As with other macrolides used in human and veterinary medicine, overdoses of MICOTIL do not produce pathognomonic lesions. The toxicity dose response varies among laboratory animal and domestic livestock species. However, clinical evidence of MICOTIL toxicity due to large doses is generally a manifestation of the positive chronotropic and negative inotropic cardiovascular effects. No adverse environmental effects are expected from the use of MICOTIL in cattle.
米考霉素300是一种用于治疗牛呼吸道疾病综合征的新型大环内酯类抗生素。与人类和兽医学中使用的其他大环内酯类药物一样，米考霉素过量使用不会产生特征性病变。毒性剂量反应在实验动物和家畜物种之间有所不同。然而，大剂量导致米考霉素中毒的临床证据通常表现为正性变时性和负性变力性心血管效应。预计在牛身上使用米考霉素不会产生不良环境影响。
