Braun Kay-P, Brookman-Amissah Sabine, Geissler Katrin, Ast Doris, May Matthias, Ernst Helmut
Praxis für Allgemeinmedizin (Inhaber: MR Dr. H.-P. Braun), Albert-Schweitzer-Strasse 11, 03050 Cottbus.
Med Klin (Munich). 2009 Mar 15;104(3):192-6. doi: 10.1007/s00063-009-1031-9. Epub 2009 Apr 1.
As yet, whole-body cryotherapy is especially used for the therapy of chronic inflammatory arthritis. An analgetic effect has been described in several studies. However, only few data exist concerning the long-term effects of this therapy.
A total of 60 patients with rheumatoid arthritis (n = 48), and ankylosing spondylitis (n = 12) was analyzed. Patients underwent treatment with whole-body cryotherapy twice a day. The average age was 55.7 +/- 10.33. The study group consisted of 48 female and twelve male patients. The average number of therapeutic treatments with cryotherapy was 15.8 +/- 8.37, the average follow-up 63.4 +/- 63.48 days.
13 patients (21.7%) discontinued treatment because of adverse effects. For patients with rheumatoid arthritis, DAS28 (Disease Activity Score) and VAS (visual analog scale) were determined. A significant reduction of both parameters was found (DAS 3.9 +/- 1.22 vs. 3.4 +/- 1.08; p < 0.01; VAS 51.4 +/- 16.62 vs. 37.9 +/- 19.13; p < 0.01). BASDAI (Bath Ankylosing Spondylitis Disease Activity Index) was analyzed for patients with ankylosing spondylitis, and also showed a significant reduction (4.4 +/- 1.91 vs. 3.1 +/- 1.34; p = 0.01).
Thus, whole-body cryotherapy is an effective option in the concept of treatment of inflammatory rheumatic diseases. The relief of pain allows an intensification of physiotherapy. A significant reduction of pain over a period of 2 months could be shown.
迄今为止，全身冷冻疗法特别用于慢性炎症性关节炎的治疗。几项研究中描述了其镇痛效果。然而，关于该疗法长期效果的数据却很少。
共分析了60例类风湿性关节炎患者（n = 48）和强直性脊柱炎患者（n = 12）。患者每天接受两次全身冷冻疗法治疗。平均年龄为55.7±10.33岁。研究组包括48例女性患者和12例男性患者。冷冻疗法的平均治疗次数为15.8±8.37次，平均随访时间为63.4±63.48天。
13例患者（21.7%）因不良反应而停止治疗。对类风湿性关节炎患者测定了疾病活动评分（DAS28）和视觉模拟评分（VAS）。发现这两个参数均显著降低（DAS：3.9±1.22对3.4±1.08；p < 0.01；VAS：51.4±16.62对37.9±19.13；p < 0.01）。对强直性脊柱炎患者分析了巴斯强直性脊柱炎疾病活动指数（BASDAI），其也显示出显著降低（4.4±1.91对3.1±1.34；p = 0.01）。
因此，全身冷冻疗法是治疗炎性风湿性疾病的一种有效选择。疼痛缓解使得物理治疗得以加强。在2个月的时间内可显示疼痛显著减轻。
