Zhao Dongbing, Wang Wenhai, Yang Fei, Lan Jingbo, Yang Li, Gao Ge, You Jingsong
Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, West China Medical School, Sichuan University, 29 Wangjiang Road, Chengdu 610064, PR China.
Angew Chem Int Ed Engl. 2009;48(18):3296-300. doi: 10.1002/anie.200900413.
A window of opportunity: A general copper-catalyzed C-H bond-activation path allows arylation of heterocycles with a wide range of aryl bromides (see scheme). The reaction shows excellent regioselectivity and exhibits good functional group tolerance. The 8-aryl xanthines exhibit fluorescence in a variety of solvents and show promise as reagents for biological imaging.
一种通用的铜催化C-H键活化途径可实现杂环与多种芳基溴的芳基化反应（见示意图）。该反应具有出色的区域选择性，并且对官能团具有良好的耐受性。8-芳基黄嘌呤在多种溶剂中均表现出荧光，有望作为生物成像试剂。
