黄芪甲苷对大鼠心力衰竭的影响。
Effects of Astragaloside IV on heart failure in rats.
机构信息
State Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin, PR China.
出版信息
Chin Med. 2009 Apr 2;4:6. doi: 10.1186/1749-8546-4-6.
Abstract
BACKGROUND
Astragaloside IV (ASI) in Radix Astragali is believed to be the active component in treating heart failure. The present study aims to examine the effects of ASI on cardiovascular parameters in long-term heart failure in rats.
METHODS
Using echocardiographic and haemodynamic measurements, we studied the effects of ASI on congestive heart failure (CHF) induced by ligation of the left coronary artery in rats.
RESULTS
ASI (0.1, 0.3 and 1.0 mg/kg/day) attenuated the decline of fractional shortening (FS). The peak derivatives of the left ventricle (LV) pressure (dp/dt) in ASI-treated groups significantly increased. Both LV internal diameters in diastole (LVIDd) and in systole (LVIDs) decreased significantly after ASI treatment (0.3 and 1.0 mg/kg/day). ASI (1.0 mg/kg/day) attenuated the decrease of LV systolic pressure (LVSP). ASI treatment inhibited compensatory hypertrophy of myocardial cells and lowered the number of apoptotic myocytes.
CONCLUSION
ASI improved cardiac functions as measured by cardiovascular parameters.
摘要
背景
黄芪中的黄芪甲苷（ASI）被认为是治疗心力衰竭的有效成分。本研究旨在探讨 ASI 对大鼠长期心力衰竭心血管参数的影响。
方法
通过超声心动图和血流动力学测量，研究 ASI 对结扎大鼠左冠状动脉引起的充血性心力衰竭（CHF）的影响。
结果
ASI（0.1、0.3 和 1.0 mg/kg/天）可减轻短轴缩短率（FS）的下降。ASI 治疗组的左心室压力（LV）峰值导数（dp/dt）显著增加。LV 舒张内径（LVIDd）和收缩内径（LVIDs）在 ASI 治疗后（0.3 和 1.0 mg/kg/天）均显著降低。ASI（1.0 mg/kg/天）可减轻 LV 收缩压（LVSP）的降低。ASI 治疗抑制心肌细胞代偿性肥大，降低凋亡心肌细胞数量。
结论
ASI 通过心血管参数改善心脏功能。
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