Department of Nutritional Sciences, University of Toronto, 50 College Street, Toronto, Ontario M5S 3E2, Canada.
Gut Pathog. 2009 Mar 19;1(1):6. doi: 10.1186/1757-4749-1-6.
Chronic fatigue syndrome (CFS) is complex illness of unknown etiology. Among the broad range of symptoms, many patients report disturbances in the emotional realm, the most frequent of which is anxiety. Research shows that patients with CFS and other so-called functional somatic disorders have alterations in the intestinal microbial flora. Emerging studies have suggested that pathogenic and non-pathogenic gut bacteria might influence mood-related symptoms and even behavior in animals and humans. In this pilot study, 39 CFS patients were randomized to receive either 24 billion colony forming units of Lactobacillus casei strain Shirota (LcS) or a placebo daily for two months. Patients provided stool samples and completed the Beck Depression and Beck Anxiety Inventories before and after the intervention. We found a significant rise in both Lactobacillus and Bifidobacteria in those taking the LcS, and there was also a significant decrease in anxiety symptoms among those taking the probiotic vs controls (p = 0.01). These results lend further support to the presence of a gut-brain interface, one that may be mediated by microbes that reside or pass through the intestinal tract.
慢性疲劳综合征（CFS）是一种病因不明的复杂疾病。在广泛的症状中，许多患者报告情绪领域出现紊乱，其中最常见的是焦虑。研究表明，CFS 患者和其他所谓的功能性躯体障碍患者的肠道微生物菌群发生了改变。新兴研究表明，致病和非致病肠道细菌可能会影响动物和人类的与情绪相关的症状，甚至行为。在这项初步研究中，39 名 CFS 患者被随机分配每天服用 240 亿个干酪乳杆菌 Shirota 株（LcS）或安慰剂，持续两个月。患者在干预前后提供粪便样本并完成贝克抑郁和贝克焦虑量表。我们发现服用 LcS 的患者中乳酸杆菌和双歧杆菌显著增加，而服用益生菌的患者与对照组相比焦虑症状显著下降（p = 0.01）。这些结果进一步支持了肠道-大脑界面的存在，这可能是由存在或通过肠道的微生物介导的。
