Nar Gokay, Sanlialp Sara Cetin, Nar Rukiye
Pamukkale University, Faculty of Medicine, Department of Cardiology, Denizli, Turkey.
Servergazi State Hospital, Department of Cardiology, Denizli, Turkey.
J Med Biochem. 2021 Sep 3;40(4):384-389. doi: 10.5937/jomb0-28846.
The previous studies have showed that serum retinol binding protein 4 (RBP4) levels increase in metabolic disorders which are closely associated with cardiovascular diseases (CVD). However, the human studies investigating the role of RBP4 in CVD are conflicted. Therefore, we aimed to evaluate the relationship between RBP4 with the presence and severity of coronary artery disease (CAD) in this study.
55 patients with presenting acute coronary syndrome (ACS) and 43 control subjects who had various cardiovascular risk factors with normal coronary artery on coronary angiography were included in this study. The serum RBP4 concentrations were measured using ELISA method, clinically and anatomically score models were used to assess the severity of coronary lesion.
Serum RBP4 levels were significantly higher in patients with ACS compared to the without ACS (68.40 ± 47.94 mg/L vs. 49.46 ± 13.64 mg/L; p = 0.014). RBP4 was correlated with GENSINI and SYNTAX I score (r = 0.286 p = 0.034; r = 0.403 p = 0.002 respectively). However, there was no relationship between RBP4 and GRACE score.
The serum RBP4 levels increase in patients with CAD and its increased levels may be correlated with CAD severity.
先前的研究表明，血清视黄醇结合蛋白4（RBP4）水平在与心血管疾病（CVD）密切相关的代谢紊乱中会升高。然而，关于RBP4在心血管疾病中作用的人体研究结果相互矛盾。因此，在本研究中我们旨在评估RBP4与冠状动脉疾病（CAD）的存在及严重程度之间的关系。
本研究纳入了55例表现为急性冠状动脉综合征（ACS）的患者和43例对照受试者，这些对照受试者有各种心血管危险因素且冠状动脉造影显示冠状动脉正常。采用酶联免疫吸附测定（ELISA）法测量血清RBP4浓度，使用临床和解剖学评分模型评估冠状动脉病变的严重程度。
与无ACS的患者相比，ACS患者的血清RBP4水平显著更高（68.40±47.94mg/L对49.46±13.64mg/L；p=0.014）。RBP4与GENSINI评分和SYNTAX I评分相关（分别为r=0.286，p=0.034；r=0.403，p=0.002）。然而，RBP4与GRACE评分之间没有关系。
CAD患者的血清RBP4水平升高，其升高水平可能与CAD严重程度相关。
