Department of Pediatrics, B. J. Wadia Hospital for Children, Parel, Mumbai, Maharashtra, India.
J Trop Pediatr. 2009 Dec;55(6):396-8. doi: 10.1093/tropej/fmp020. Epub 2009 Apr 1.
We retrospectively studied seven children (six girls, one boy) aged from 7.5 to 25 months who presented to our institution after taking large doses of vitamin D (900 000-4 000 000 U) prescribed by medical practitioners for wrong indications like failure to thrive, etc. The clinical manifestations were constipation, decreased appetite, lethargy, polyuria, dehydration and failure to thrive. All patients had hypercalcemia (serum calcium ranging from 12 to 16.8 mg/dl), high 25[OH]D levels (ranging from 96 to >150 ng/ml), suppressed intact parathyroid hormone (ranging from <3 to 8.1 pg/ml). Hypercalciuria (urinary calcium/creatinine ranging from 1 to 2.45) was found in all patients, while nephrocalcinosis was present in five patients. All were treated with intravenous fluids, oral prednisolone, restriction of calcium in diet, while four patients received pamidronate infusion for reducing hypercalcemia.
我们回顾性研究了 7 名儿童（6 名女孩，1 名男孩），他们在服用医生开出的大剂量维生素 D（900 000-4 000 000 U）后因错误的适应症（如生长不良等）就诊于我们的机构。临床表现为便秘、食欲不振、嗜睡、多尿、脱水和生长不良。所有患者均有高钙血症（血清钙 12-16.8mg/dl）、25[OH]D 水平升高（96-＞150ng/ml）、完整甲状旁腺激素抑制（＜3-8.1pg/ml）。所有患者均有高钙尿症（尿钙/肌酐 1-2.45），5 名患者有肾钙质沉着症。所有患者均接受静脉补液、口服泼尼松龙、限制饮食中的钙，4 名患者接受帕米膦酸盐输注以降低血钙。
