Hayes Tamara L, Larimer Nicole, Adami Andre, Kaye Jeffrey A
Division of Biomedical Engineering, Oregon Health & Sciences University, 3303 SW Bond Avenue, Portland, OR 97239, USA.
J Aging Health. 2009 Jun;21(4):567-80. doi: 10.1177/0898264309332836. Epub 2009 Apr 1.
This was a cross-sectional study of the ability of independently living healthy elders to follow a medication regimen. Participants were divided into a group with High Cognitive Function (HCF) or Low Cognitive Function (LCF) based on their scores on the ADAS-Cog.
Thirty-eight participants aged 65 or older and living independently in the community followed a twice-daily vitamin C regimen for 5 weeks. Adherence was measured using an electronic 7-day pillbox.
The LCF group had significantly poorer total adherence than the HCF group (LCF: 63.9 +/- 11.2%, HCF: 86.8 +/- 4.3%, t( 36) = 2.57, p = .007), and there was a 4.1 relative risk of non-adherence in the LCF group as compared to the HCF group.
This study has important implications for the conduct of clinical drug trials, as it provides strong evidence that even very mild cognitive impairment in healthy elderly has a detrimental impact on medication adherence.
这是一项关于独立生活的健康老年人遵循药物治疗方案能力的横断面研究。根据参与者在阿尔茨海默病协作研究认知量表（ADAS-Cog）上的得分，将其分为高认知功能（HCF）组或低认知功能（LCF）组。
38名65岁及以上且独立生活在社区的参与者，每天两次服用维生素C，持续5周。使用电子7天药盒测量依从性。
LCF组的总依从性显著低于HCF组（LCF：63.9 +/- 11.2%，HCF：86.8 +/- 4.3%，t(36) = 2.57，p = 0.007），与HCF组相比，LCF组不依从的相对风险为4.1。
本研究对临床药物试验具有重要意义，因为它提供了有力证据，表明即使是健康老年人中非常轻微的认知障碍也会对药物依从性产生不利影响。
