Seale Patrick, Kajimura Shingo, Spiegelman Bruce M
Dana-Farber Cancer Institute, Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Genes Dev. 2009 Apr 1;23(7):788-97. doi: 10.1101/gad.1779209.
The last several years have seen an explosion of information relating to the transcriptional control of brown fat cell development. At the same time, new data have emerged that clearly demonstrate that adult humans do indeed have substantial amounts of functioning brown adipose tissue (BAT). Together, these advances are stimulating a reassessment of the role of brown adipose tissue in human physiology and pathophysiology. These data have also opened up exciting new opportunities for the development of entirely novel classes of therapeutics for metabolic diseases like obesity and type 2 diabetes.
在过去几年里，与棕色脂肪细胞发育的转录调控相关的信息呈爆发式增长。与此同时，新的数据表明，成年人体内确实存在大量具有功能的棕色脂肪组织（BAT）。这些进展共同促使人们重新评估棕色脂肪组织在人类生理和病理生理中的作用。这些数据也为开发针对肥胖和2型糖尿病等代谢性疾病的全新治疗方法带来了令人兴奋的新机遇。
