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UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality.解偶联蛋白1（UCP1）缺失会诱发小鼠肥胖，并消除因处于热中性环境而免受热应激影响的小鼠的饮食诱导产热。
Cell Metab. 2009 Feb;9(2):203-9. doi: 10.1016/j.cmet.2008.12.014.
2
Genome-wide profiling of PPARgamma:RXR and RNA polymerase II occupancy reveals temporal activation of distinct metabolic pathways and changes in RXR dimer composition during adipogenesis.全基因组范围内PPARγ:RXR和RNA聚合酶II占据情况分析揭示脂肪生成过程中不同代谢途径的时间性激活以及RXR二聚体组成的变化。
Genes Dev. 2008 Nov 1;22(21):2953-67. doi: 10.1101/gad.501108.
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PPARgamma and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale.过氧化物酶体增殖物激活受体γ（PPARγ）和CCAAT增强子结合蛋白（C/EBP）因子通过全基因组范围内的相邻结合来调控脂肪细胞生物学。
Genes Dev. 2008 Nov 1;22(21):2941-52. doi: 10.1101/gad.1709008.
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The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1{alpha}.SRC-3的基因消融通过减少PGC-1α的乙酰化来预防肥胖并改善胰岛素敏感性。
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Distinct expression of muscle-specific microRNAs (myomirs) in brown adipocytes.棕色脂肪细胞中肌肉特异性微小RNA（肌微RNA）的独特表达。
J Cell Physiol. 2009 Feb;218(2):444-9. doi: 10.1002/jcp.21621.
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Quantitative assessment of FDG uptake in brown fat using standardized uptake value and dual-time-point scanning.使用标准化摄取值和双时相扫描对棕色脂肪中氟代脱氧葡萄糖摄取进行定量评估。
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Science. 2008 Oct 24;322(5901):583-6. doi: 10.1126/science.1156232. Epub 2008 Sep 18.
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PRDM16 controls a brown fat/skeletal muscle switch.PRDM16控制棕色脂肪/骨骼肌转换。
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棕色脂肪细胞发育和生理功能的转录调控——小鼠与人的研究

Transcriptional control of brown adipocyte development and physiological function--of mice and men.

作者信息

Seale Patrick, Kajimura Shingo, Spiegelman Bruce M

机构信息

Dana-Farber Cancer Institute, Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.

出版信息

Genes Dev. 2009 Apr 1;23(7):788-97. doi: 10.1101/gad.1779209.

DOI:10.1101/gad.1779209
PMID:19339685
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2763499/
Abstract

The last several years have seen an explosion of information relating to the transcriptional control of brown fat cell development. At the same time, new data have emerged that clearly demonstrate that adult humans do indeed have substantial amounts of functioning brown adipose tissue (BAT). Together, these advances are stimulating a reassessment of the role of brown adipose tissue in human physiology and pathophysiology. These data have also opened up exciting new opportunities for the development of entirely novel classes of therapeutics for metabolic diseases like obesity and type 2 diabetes.

摘要

在过去几年里，与棕色脂肪细胞发育的转录调控相关的信息呈爆发式增长。与此同时，新的数据表明，成年人体内确实存在大量具有功能的棕色脂肪组织（BAT）。这些进展共同促使人们重新评估棕色脂肪组织在人类生理和病理生理中的作用。这些数据也为开发针对肥胖和2型糖尿病等代谢性疾病的全新治疗方法带来了令人兴奋的新机遇。