Joëls Marian, Baram Tallie Z
SILS-CNS, University of Amsterdam, the Netherlands.
Nat Rev Neurosci. 2009 Jun;10(6):459-66. doi: 10.1038/nrn2632.
The impact of stress on brain function is increasingly recognized. Various substances are released in response to stress and can influence distinct neuronal circuits, but the functional advantages of having such a diversity of stress mediators remain unclear. Individual neurotransmitter, neuropeptide and steroid stress mediators have specific spatial and temporal niches, but these niches also overlap. In addition, the effects of individual mediators on neuronal function and plasticity are integrated, and emerging evidence suggests that there is crosstalk between them. Together, this results in the stress instruments producing an orchestrated 'symphony' that enables fine-tuned responses to diverse challenges.
压力对大脑功能的影响日益受到认可。应激反应会释放各种物质,这些物质可影响不同的神经回路,但拥有如此多样的应激介质的功能优势仍不清楚。个体神经递质、神经肽和类固醇应激介质具有特定的时空定位,但这些定位也存在重叠。此外,个体介质对神经元功能和可塑性的影响是综合的,新出现的证据表明它们之间存在相互作用。总之,这使得应激工具产生一场精心编排的“交响乐”,从而能够对各种挑战做出微调反应。