Cohen Alan A, Picard Martin, Beard John R, Belsky Daniel W, Herbstman Julie, Kuryla Christine L, Liu Molei, Makarem Nour, Malinsky Daniel, Pei Sen, Wei Ying, Fried Linda P
Robert N. Butler Columbia Aging Center, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
Sci Adv. 2025 Jun 20;11(25):eadu8437. doi: 10.1126/sciadv.adu8437. Epub 2025 Jun 18.
The health sciences largely focus on disease. However, the interconnected determinants of diseases suggest that we need a science of health, a framework to examine the biology of homeodynamics in a changing environment and how this affects the health we value. We build on first principles and recent discoveries on biological system dynamics to develop the concept of intrinsic health, a field-like state emerging from the dynamic interplay of energy, communication, and structure within the organism, giving rise to robustness/resilience, plasticity, performance, and sustainability. Intrinsic health is a quantifiable property of individuals that declines with age and interacts with context. We propose a measurement framework and describe how it will contribute to achieving the shared goals of medicine and public health.
健康科学主要关注疾病。然而，疾病相互关联的决定因素表明，我们需要一门健康科学，一个在不断变化的环境中审视内稳态生物学以及这如何影响我们所珍视的健康的框架。我们基于生物学系统动力学的第一原理和最新发现，来发展内在健康的概念，内在健康是一种类似场的状态，它源于生物体内部能量、通讯和结构的动态相互作用，产生稳健性/恢复力、可塑性、性能和可持续性。内在健康是个体的一种可量化属性，会随着年龄增长而下降，并与环境相互作用。我们提出了一个测量框架，并描述了它将如何有助于实现医学和公共卫生的共同目标。
