Aste N, Viglietti-Panzica C, Fasolo A, Andreone C, Vaudry H, Pelletier G, Panzica G C
Department of Human Anatomy and Physiology, University of Torino, Italy.
Cell Tissue Res. 1991 Aug;265(2):219-30. doi: 10.1007/BF00398070.
In the present study, we have demonstrated, by means of the biotin-avidin method, the widespread distribution of neuropeptide Y (NPY)-immunoreactive structures throughout the whole brain of the Japanese quail (Coturnix coturnix japonica). The prosencephalic region contained the highest concentration of both NPY-containing fibres and perikarya. Immunoreactive fibres were observed throughout, particularly within the paraolfactory lobe, the lateral septum, the nucleus taeniae, the preoptic area, the periventricular hypothalamic regions, the tuberal complex, and the ventrolateral thalamus. NPY-immunoreactive cells were represented by: a) small scattered perikarya in the telencephalic portion (i.e. archistriatal, neostriatal and hyperstriatal regions, hippocampus, piriform cortex); b) medium-sized cell bodies located around the nucleus rotundus, ventrolateral, and lateral anterior thalamic nuclei; c) small clustered cells within the periventricular and medial preoptic nuclei. The brainstem showed a less diffuse innervation, although a dense network of immunopositive fibres was observed within the optic tectum, the periaqueductal region, and the Edinger-Westphal, linearis caudalis and raphes nuclei. Two populations of large NPY-containing perikarya were detected: one located in the isthmic region, the other at the boundaries of the pons with the medulla. The wide distribution of NPY-immunoreactive structures within regions that have been demonstrated to play a role in the control of vegetative, endocrine and sensory activities suggests that, in birds, this neuropeptide is involved in the regulation of several aspects of cerebral functions.
在本研究中，我们通过生物素-抗生物素蛋白方法证明，神经肽Y（NPY）免疫反应性结构广泛分布于日本鹌鹑（Coturnix coturnix japonica）的整个大脑中。前脑区域含有含NPY纤维和神经核的最高浓度。在整个区域都观察到免疫反应性纤维，特别是在副嗅叶、外侧隔、带状核、视前区、室周下丘脑区域、结节复合体和腹外侧丘脑内。NPY免疫反应性细胞表现为：a）端脑部分（即古纹状体、新纹状体和上纹状体区域、海马体、梨状皮质）中散在的小神经核；b）位于圆核、腹外侧和丘脑前外侧核周围的中等大小细胞体；c）室周和内侧视前核内的小簇状细胞。脑干的神经支配较不弥散，尽管在视顶盖、导水管周围区域以及动眼神经副核、尾侧线性核和中缝核内观察到密集的免疫阳性纤维网络。检测到两类含大量NPY的神经核：一类位于峡部区域，另一类位于脑桥与延髓的边界处。NPY免疫反应性结构在已证明在控制植物性、内分泌和感觉活动中起作用的区域内广泛分布，这表明在鸟类中，这种神经肽参与大脑功能多个方面的调节。
