Schulz Christian, von Andrian Ulrich H, Massberg Steffen
Deutsches Herzzentrum, Technische Universität München, Lazarettstrasse 36, 80636, Munich, Germany.
Immunol Res. 2009;44(1-3):160-8. doi: 10.1007/s12026-009-8109-6.
Hematopoietic stem and progenitor cells (HSPCs) are a rare population of precursor cells that possess the capacity for self-renewal and multilineage differentiation. In the bone marrow (BM), HSPCs warrant blood cell homeostasis. In addition, they may also replenish tissue-resident myeloid cells and directly participate in innate immune responses once they home to peripheral tissues. In this review, we summarize recent data on the signaling molecules that modulate the mobilization of HSPCs from BM and their migration to peripheral tissues.
造血干细胞和祖细胞（HSPCs）是一类罕见的前体细胞，具有自我更新和多谱系分化的能力。在骨髓（BM）中，HSPCs维持血细胞的稳态。此外，一旦归巢到外周组织，它们还可能补充组织驻留髓样细胞并直接参与固有免疫反应。在本综述中，我们总结了关于调节HSPCs从骨髓动员及其向外周组织迁移的信号分子的最新数据。
