Kuleshova E P, Dolbakyan E E, Grigor'yan G A, Merzhanova G Kh
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia.
Neurosci Behav Physiol. 2009 May;39(4):387-94. doi: 10.1007/s11055-009-9138-2. Epub 2009 Apr 2.
In behavioral experiments, cats placed in a situation of choosing between a high-value time-delayed and a low-value rapid food reinforcement elected to wait for the preferred reward (they demonstrated "self-control") or to obtain the worse reward quickly (they demonstrated impulsive behavior). On the basis of the selected behavioral strategy, the cats were divided into three groups - "impulsive," "ambivalent," and "self-controlled." Cross-correlation analysis was used to assess the linked activity of cells in the nucleus accumbens, which reflects the nature of interactions between close-lying neurons. In cats with self-control, interneuronal interactions appeared in a significantly larger proportion of cases than in impulsive cats. In combinations resulting in long-latency reactions, cats with self-controlled and impulsive behavior showed no significant difference in the occurrence frequency of interneuronal interactions. The numbers of interneuronal interactions were greater during erroneous responses as compared with correctly performed reactions in animals of the different groups. These data indicate a key role for the interrelated activity of nucleus accumbens neurons in organizing the pattern of long-latency responses typical of self-controlled behavior.
在行为实验中，将猫置于在高价值延迟食物奖励和低价值即时食物奖励之间进行选择的情境中，它们要么选择等待偏好的奖励（表现出“自我控制”），要么迅速获取较差的奖励（表现出冲动行为）。根据所选的行为策略，猫被分为三组——“冲动型”、“矛盾型”和“自我控制型”。采用互相关分析来评估伏隔核中细胞的关联活动，这反映了相邻神经元之间相互作用的性质。与冲动型猫相比，自我控制型猫在更大比例的情况下出现了神经元间相互作用。在导致长潜伏期反应的组合中，自我控制型和冲动型行为的猫在神经元间相互作用的发生频率上没有显著差异。与不同组动物正确执行反应相比，错误反应期间神经元间相互作用的数量更多。这些数据表明伏隔核神经元的相互关联活动在组织自我控制行为典型的长潜伏期反应模式中起关键作用。
