Silant'eva D I, Gainutdinova T Kh, Andrianov V V, Gainutdinov Kh L
Biophysics Laboratory, Kazan Physicotechnical Institute, Kazan Scientific Center, Russian Academy of Sciences, Kazan, Russia.
Neurosci Behav Physiol. 2009 May;39(4):403-7. doi: 10.1007/s11055-009-9136-4. Epub 2009 Apr 2.
Chronic administration of caffeine to common snails increased the rate of formation of a conditioned defensive reflex. When daily caffeine injections were given immediately after the training procedure, the conditioned defensive reflex was acquired more quickly than when caffeine injections were given before the training procedure started. Chronic caffeine administration to both trained and untrained snails led to depolarization changes in the membrane potential and reductions in the threshold potential of defensive behavior command neurons in common snails. Comparative studies showed that addition of caffeine to the solution bathing the mollusk nervous system resulted in decreases in the threshold potential of command neurons in both intact and trained snails; there was, however, no change in the membrane resting potential.
对普通蜗牛长期给予咖啡因可提高条件性防御反射的形成速率。当在训练程序结束后立即每日注射咖啡因时，与在训练程序开始前注射咖啡因相比，条件性防御反射的获得更快。对经过训练和未经训练的蜗牛长期给予咖啡因，会导致普通蜗牛膜电位的去极化变化以及防御行为指令神经元阈电位的降低。比较研究表明，向浸泡软体动物神经系统的溶液中添加咖啡因会导致完整蜗牛和受过训练的蜗牛的指令神经元阈电位降低；然而，膜静息电位没有变化。
