Inamori Y, Baba K, Tsujibo H, Taniguchi M, Nakata K, Kozawa M
Osaka University of Pharmaceutical Sciences, Japan.
Chem Pharm Bull (Tokyo). 1991 Jun;39(6):1604-5. doi: 10.1248/cpb.39.1604.
Two chalcones, xanthoangelol (I) and 4-hydroxyderricin (II), isolated from the root of Angelica keiskei KOIDZUMI (Umbelliferae) showed antibacterial activity against gram-positive pathogenic bacteria. The activity of I on Micrococcus luteus IFO-12708 (minimum inhibitory concentration (MIC), 0.76 microgram/ml) was the same potency as that of gentamicin, which is used as a standard. Although the activity of both chalcones on plant-pathogenic bacteria was lower than that of streptomycin sulfate, used as a positive control, they also exhibited growth-inhibitory effects. The antibacterial activity of I isolated from Angelica keiskei KOIDZUMI is being reported here for the first time. The growth-inhibitory effect of II on plant-pathogenic bacteria is also reported for the first time in this paper.
从明日叶（伞形科）根部分离得到的两种查耳酮，即黄当归醇（I）和4-羟基德里辛（II），对革兰氏阳性病原菌具有抗菌活性。I对藤黄微球菌IFO-12708的活性（最低抑菌浓度（MIC）为0.76微克/毫升）与用作标准的庆大霉素相同。虽然这两种查耳酮对植物病原菌的活性低于用作阳性对照的硫酸链霉素，但它们也表现出生长抑制作用。本文首次报道了从明日叶中分离得到的I的抗菌活性。本文也首次报道了II对植物病原菌的生长抑制作用。
