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针对开始服用口服避孕药的女性的单包与多包包装:两种分发方案的比较

One versus multiple packs for women starting oral contraceptive pills: a comparison of two distribution regimens.

作者信息

Chin-Quee Dawn, Otterness Conrad, Wedderburn Maxine, McDonald Olivia, Janowitz Barbara

机构信息

Family Health International, Durham, NC 27713, USA.

出版信息

Contraception. 2009 May;79(5):369-74. doi: 10.1016/j.contraception.2008.11.013.

Abstract

BACKGROUND

Despite World Health Organization and International Planned Parenthood Federation recommendations to provide multiple pill cycles to new users, many programs in developing countries still give only one pill cycle to new acceptors.

STUDY DESIGN

To compare provision of a single versus multiple packs of pills, new pill users in 20 matched public sector clinics in Jamaica were assigned to one of two pill regimens in which they received either one (then subsequently three) or four pill cycles at method initiation. The primary outcome was the proportion of women who used pills beyond 4 months.

RESULTS

Among 655 women, those receiving one cycle of pills at initiation, followed by counseling and a three-pack resupply, were no more likely to be using pills after 4 months than women who received four packs at initiation (odds ratio=1.33; 95% confidence interval=0.88-2.0). In both pill regimen groups, returning late to the clinic for resupply was a problem. However, more women in the 1+3-pack regimen group returned late to study clinics to obtain their fifth cycle of pills than their counterparts in the 4-pack regimen group (53% vs. 28%).

CONCLUSION

Our findings support the recommendation that pill users should be given more than one cycle to start, because an extra visit for resupply contributes to clinic and provider costs. Moreover, providing more pill cycles at initiation would decrease the likelihood that women experience a gap in pill use between cycles.

摘要

背景

尽管世界卫生组织和国际计划生育联合会建议为新使用者提供多个服药周期,但发展中国家的许多项目仍只为新接受者提供一个服药周期。

研究设计

为比较提供单包与多包避孕药的情况,牙买加20家匹配的公共部门诊所的新避孕药使用者被分配到两种服药方案之一,在开始使用该方法时,她们要么接受一个(随后三个)服药周期,要么接受四个服药周期。主要结果是服药超过4个月的女性比例。

结果

在655名女性中,开始时接受一个服药周期,随后接受咨询和三包补充供应的女性,在4个月后继续服药的可能性并不高于开始时接受四包的女性(优势比=1.33;95%置信区间=0.88 - 2.0)。在两个服药方案组中,返回诊所补充供应延迟都是一个问题。然而,1 + 3包方案组中返回研究诊所获取第五个服药周期的女性比4包方案组中的女性更多(53%对28%)。

结论

我们的研究结果支持以下建议,即应该给避孕药使用者提供不止一个周期的起始药量,因为额外的补充供应访视会增加诊所和提供者的成本。此外,开始时提供更多服药周期将降低女性在周期之间出现服药间隔的可能性。

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