Frueh B Christopher, Grubaugh Anouk L, Cusack Karen J, Kimble Matthew O, Elhai Jon D, Knapp Rebecca G
The Menninger Clinic and Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, 2801 Gessner Dr., Houston, TX 77080, United States.
J Anxiety Disord. 2009 Jun;23(5):665-75. doi: 10.1016/j.janxdis.2009.02.005. Epub 2009 Feb 14.
In an open trial design, adults (n=20) with posttraumatic stress disorder (PTSD) and either schizophrenia or schizoaffective disorder were treated via an 11-week cognitive-behavioral intervention for PTSD that consisted of education, anxiety management therapy, social skills training, and exposure therapy, provided at community mental health centers. Results offer preliminary hope for effective treatment of PTSD among adults with schizophrenia or schizoaffective disorder, especially among treatment completers (n=13). Data showed significant PTSD symptom improvement, maintained at 3-month follow-up. Further, 12 of 13 completers no longer met criteria for PTSD or were considered treatment responders. Clinical outcomes for other targeted domains (e.g., anger, general mental health) also improved and were maintained at 3-month follow-up. Participants evidenced high treatment satisfaction, with no adverse events. Significant improvements were not noted on depression, general anxiety, or physical health status. Future directions include the need for randomized controlled trials and dissemination efforts.
在一项开放试验设计中，患有创伤后应激障碍（PTSD）且伴有精神分裂症或分裂情感性障碍的成年人（n = 20），在社区心理健康中心接受了为期11周的针对PTSD的认知行为干预，该干预包括教育、焦虑管理疗法、社交技能训练和暴露疗法。结果为有效治疗患有精神分裂症或分裂情感性障碍的成年人中的PTSD带来了初步希望，尤其是在治疗完成者（n = 13）中。数据显示PTSD症状有显著改善，并在3个月随访时得以维持。此外，13名完成者中有12名不再符合PTSD标准或被视为治疗有反应者。其他目标领域（如愤怒、总体心理健康）的临床结果也有所改善，并在3个月随访时得以维持。参与者对治疗满意度很高，且无不良事件。在抑郁、一般焦虑或身体健康状况方面未观察到显著改善。未来的方向包括需要进行随机对照试验和推广工作。
