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研究英国二级医疗服务中患者的创伤、创伤后应激障碍与精神病之间的关系。

Examining the Relationship Between Trauma, Post-Traumatic Stress Disorder and Psychosis in Patients in a UK Secondary Care Service.

作者信息

Martin David, Philips Michelle, Greenstone Harriet, Davies Jonathan, Stewart Guy, Ewins Elizabeth, Zammit Stan

机构信息

Centre for Academic Mental Health, Population Health Sciences Bristol Medical School University of Bristol Bristol UK.

Avon and Wiltshire Mental Health Partnership NHS Trust Bath UK.

出版信息

Psychiatr Res Clin Pract. 2023 Jan 20;5(2):51-59. doi: 10.1176/appi.prcp.20220028. eCollection 2023 Summer.

Abstract

OBJECTIVE

Traumatic experiences and post-traumatic stress disorder (PTSD) are common in schizophrenia. However, few studies screening for PTSD have established the temporality of PTSD-related traumatic events to psychosis onset. Furthermore, it is unclear how many patients attribute a trauma-based contribution to their psychosis or would find trauma-focused therapy acceptable. We examine the prevalence and timing of trauma in psychosis, as well as patient views on the relationship between their trauma experiences and mental health difficulties, and on receiving trauma-focused therapy.

METHODS

Sixty-eight patients with an at-risk mental state (ARMS) or psychotic disorder in a UK secondary-care setting completed self-report measures of trauma and PTSD, and undertook research interviews. Proportions and odds ratios were derived with 95% confidence intervals.

RESULTS

We recruited 68 participants (estimated response rate 62%; psychotic disorder  = 61, ARMS  = 7). Sixty three (95%) reported traumatic events and 32 (47%) reported childhood abuse. Twenty-six individuals (38%) met criteria for PTSD, though for >95% this was not recorded in their notes, and 25 (37%) had sub-threshold PTSD. For 69% of participants, their worst trauma occurred before the onset of their psychosis symptoms. Most (65%) believed their psychosis symptoms were related to past traumas and 82% of these were interested in receiving trauma-focused therapy.

CONCLUSIONS

PTSD is common in and often pre-dates onset of psychosis. Most patients believe their symptoms and traumas are related and would be interested in trauma-focused therapy if available. Studies evaluating the effectiveness of trauma-focused therapies for those with or at high-risk of psychosis are required.

摘要

目的

创伤经历和创伤后应激障碍(PTSD)在精神分裂症中很常见。然而,很少有筛查PTSD的研究确定与PTSD相关的创伤事件与精神病发作之间的时间关系。此外,尚不清楚有多少患者将基于创伤的因素归因于他们的精神病,或者会认为以创伤为重点的治疗是可以接受的。我们研究了精神病中创伤的患病率和发生时间,以及患者对其创伤经历与心理健康问题之间关系的看法,以及对接受以创伤为重点的治疗的看法。

方法

在英国二级护理机构中,68名处于精神状态风险(ARMS)或患有精神障碍的患者完成了创伤和PTSD的自我报告测量,并接受了研究访谈。得出比例和比值比,并给出95%置信区间。

结果

我们招募了68名参与者(估计应答率为62%;精神障碍患者 = 61名,ARMS患者 = 7名)。63人(95%)报告有创伤事件,32人(47%)报告有童年期受虐经历。26人(38%)符合PTSD标准,不过超过95%的情况在他们的病历中未记录,25人(37%)有亚阈值PTSD。对于69%的参与者,他们最严重的创伤发生在精神病症状发作之前。大多数人(65%)认为他们的精神病症状与过去的创伤有关,其中82%的人有兴趣接受以创伤为重点的治疗。

结论

PTSD在精神病中很常见,且通常在精神病发作之前出现。大多数患者认为他们的症状与创伤有关,如果有以创伤为重点的治疗,他们会有兴趣接受。需要开展研究评估以创伤为重点的治疗方法对患有精神病或有精神病高风险者的有效性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44df/10245461/45c2ca91d6dd/RCP2-5-51-g002.jpg

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