Wang Jing, Jiang Baoguo, Marshall Roger J, Zhang Peixun
Department of Orthopedics and Trauma, Peking University People's Hospital, South Xi-Zhi-Men Street 11, Beijing, People's Republic of China, 100044.
Int Orthop. 2009 Oct;33(5):1179-87. doi: 10.1007/s00264-009-0763-8. Epub 2009 Apr 3.
We conducted an up-to-date meta-analysis of 20 eligible randomised controlled trials (RCTs) containing 3,109 patients to compare arthroplasty with internal fixation of displaced femoral neck fractures regarding the effect on clinical outcomes. Computerised databases were searched for RCTs published from January 1979 to May 2008. The results showed that compared to internal fixation arthroplasty led to significantly fewer surgical complications at two and five years postoperatively and reduced the incidence of reoperation at one, two and five years postoperatively (P < 0.001). However, arthroplasty was associated with greater risk of deep wound infection, longer operating time and greater operative blood loss. Arthroplasty substantially increased the risk of reoperation following deep wound infection (P < 0.05). For mortality, there was increased postoperative risk for arthroplasty compared with internal fixation, but there was no statistically significant difference between the two groups at the different follow-up times. For pain at one year postoperatively, the result showed no statistically significant difference.
我们对20项符合条件的随机对照试验(RCT)进行了最新的荟萃分析,这些试验包含3109例患者,旨在比较置换术与移位型股骨颈骨折内固定术对临床结局的影响。通过计算机检索1979年1月至2008年5月发表的RCT。结果显示,与内固定相比,置换术在术后两年和五年时导致的手术并发症显著减少,且在术后一年、两年和五年时降低了再次手术的发生率(P < 0.001)。然而,置换术与深部伤口感染风险增加、手术时间延长和术中失血量增加有关。深部伤口感染后,置换术显著增加了再次手术的风险(P < 0.05)。在死亡率方面,与内固定相比,置换术术后风险增加,但在不同随访时间两组之间无统计学显著差异。对于术后一年的疼痛,结果显示无统计学显著差异。