"L'Aquila per la Vita" Home Care Service, L'Aquila, Italy.
Support Care Cancer. 2010 Jan;18(1):77-81. doi: 10.1007/s00520-009-0632-4. Epub 2009 Apr 3.
The goal of this study is to evaluate the feasibility and efficacy of palliative sedation at home (PSH) to approach refractory symptoms in dying cancer patients.
Charts of 121 patients, observed by "L'Aquila per la Vita" Home Care Unit, from August 2006 to May 2008, were reviewed. Sixteen patients out of 44 who died at home (36.4%) were sedated. Indication for sedation was agitated delirium in 13 patients and dyspnea in three patients. A multistep midazolam-based protocol was administered.
In all patients, a deep, prolonged, continuous sedation was obtained. No treatment-related complications were registered.
A midazolam-based protocol for PSH is feasible and effective. Our results need to be confirmed by prospective, multicentric, controlled studies.
本研究旨在评估姑息性镇静在家中（PSH）治疗临终癌症患者难治性症状的可行性和疗效。
回顾了“L'Aquila per la Vita”家庭护理小组于 2006 年 8 月至 2008 年 5 月观察的 121 名患者的病历。在 44 名在家中死亡的患者中，有 16 名（36.4%）接受了镇静治疗。镇静的指征是 13 例意识混乱和激越，3 例呼吸困难。采用了一种基于咪达唑仑的多步骤方案。
所有患者均获得深度、持久、持续的镇静。未发生与治疗相关的并发症。
基于咪达唑仑的 PSH 方案是可行和有效的。我们的结果需要通过前瞻性、多中心、对照研究来证实。
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