Buffet P, Danchin N, Villemot J P, Amrein D, Ethevenot G, Juillière Y, Mathieu P, Cherrier F
Départment des Maladies CardioVasculaires, Chu Nancy-Brabois, Vandoeuvre-lès-Nancy, France.
Circulation. 1991 Nov;84(5 Suppl):III254-9.
From April 1980 to January 1990, among 2,576 percutaneous transluminal coronary angioplasty (PTCA) procedures, 100 patients (82 men and 18 women; mean age, 54 +/- 10 years [3.9%]) underwent emergency coronary artery bypass graft surgery. Before PTCA 56 had unstable angina, 34 had prior myocardial infarction, and 60 had single-vessel coronary artery disease. The mean time period from the onset of ischemia to surgical reperfusion was 147 +/- 16 minutes; 155 grafts were placed (1.5 grafts per patient). In-hospital mortality was 19%; operative mortality was significantly related to older age (59 +/- 9 versus 53 +/- 10 years, p less than 0.05), presence of unstable angina (74% versus 53%, p less than 0.05), and development of cardiogenic shock or necessity of cardiac massage before surgery (53% versus 16%, p less than 0.0001). In addition, 57 patients developed a Q wave myocardial infarction. For hospital survivors, overall survival at 7 years was 94% (Kaplan-Meier method), with three cardiac deaths during follow-up; two additional patients had late myocardial infarction, and four had late PTCA. At a mean follow-up of 55 +/- 38 months, 78% of the patients had no chest pain, and 80% reported no dyspnea. All patients received antiplatelet agents or oral anticoagulants; 34% had no antianginal medications. Among the 40 previously employed patients, 73% resumed work after surgery. All patients with cardiogenic shock or cardiac massage who survived the initial hospital period were alive at follow-up. After an initial critical period, the long-term clinical outcome of patients with emergency coronary bypass surgery after failed PTCA is satisfactory.
1980年4月至1990年1月,在2576例经皮腔内冠状动脉成形术(PTCA)中,100例患者(82例男性和18例女性;平均年龄54±10岁[3.9%])接受了急诊冠状动脉旁路移植术。PTCA术前,56例有不稳定型心绞痛,34例有既往心肌梗死,60例有单支冠状动脉疾病。从缺血发作到手术再灌注的平均时间为147±16分钟;共植入155支移植血管(每位患者1.5支)。住院死亡率为19%;手术死亡率与年龄较大(59±9岁对53±10岁,p<0.05)、存在不稳定型心绞痛(74%对53%,p<0.05)以及术前发生心源性休克或需要心脏按摩(53%对16%,p<0.0001)显著相关。此外,57例患者发生了Q波心肌梗死。对于医院幸存者,7年总生存率为94%(Kaplan-Meier法),随访期间有3例心脏死亡;另有2例患者发生晚期心肌梗死,4例接受晚期PTCA。平均随访55±38个月时,78%的患者无胸痛,80%的患者报告无呼吸困难。所有患者均接受抗血小板药物或口服抗凝剂治疗;34%的患者无需抗心绞痛药物。在40例既往有工作的患者中,73例术后恢复工作。所有在初始住院期间存活的心源性休克或接受心脏按摩的患者在随访时均存活。经过最初的关键时期后,PTCA失败后接受急诊冠状动脉搭桥手术患者的长期临床结局令人满意。