Sievers B, Schofer J, Kalmar P, Krebber H J, Bleifeld W
Abteilung für Kardiologie, Universitätskrankenhaus Eppendorf, Hamburg.
Z Kardiol. 1991 Aug;80(8):506-11.
Between 1980 and 1988, percutaneous transluminal coronary angioplasty (PTCA) was performed in 1,514 patients. Fifty-five patients (3.6%) underwent emergency coronary bypass surgery because of an acute occlusion of the vessel or a dissection with sustained angina and signs of ischemia on the electrocardiogram. Twenty-five of these 55 patients had a myocardial infarction and 5 patients died, 3 perioperatively, 2 after hospital discharge. The degree of stenosis of the dilated vessel significantly influenced the incidence of infarction, while left ventricular ejection fraction prior to PTCA significantly influenced mortality. Patients who underwent surgery with an occluded vessel experienced myocardial infarction significantly more often (87%) than patients with a patent vessel (24%). The incidence of infarction was 27% when reperfusion of the vessel occluded during PTCA was achieved with a reperfusion catheter, repeated PTCA or intracoronary lysis. The patients' age, presence of unstable angina, left ventricular ejection fraction prior to PTCA, the dilated vessel, the extent of coronary artery disease, collateralization of the dilated vessel, and the time between the onset of the event necessitating bypass surgery and the beginning of extracorporeal circulation were found to have no influence on the incidence of infarction. Patients who died had a significantly lower ejection fraction before PTCA than survivors and all patients who died had experienced a large perioperative myocardial infarction.
1980年至1988年间,1514例患者接受了经皮腔内冠状动脉成形术(PTCA)。55例患者(3.6%)因血管急性闭塞或夹层伴持续性心绞痛及心电图缺血征象而接受了急诊冠状动脉搭桥手术。这55例患者中有25例发生心肌梗死,5例死亡,3例死于围手术期,2例于出院后死亡。扩张血管的狭窄程度显著影响梗死发生率,而PTCA术前左心室射血分数显著影响死亡率。血管闭塞的患者接受手术时发生心肌梗死的频率(87%)显著高于血管通畅的患者(24%)。当通过再灌注导管、重复PTCA或冠状动脉内溶栓实现PTCA期间闭塞血管的再灌注时,梗死发生率为27%。研究发现,患者的年龄、不稳定型心绞痛的存在、PTCA术前左心室射血分数、扩张血管、冠状动脉疾病的范围、扩张血管的侧支循环以及需要进行搭桥手术的事件发生与体外循环开始之间的时间,均对梗死发生率无影响。死亡患者PTCA术前的射血分数显著低于存活者,且所有死亡患者均经历了大面积围手术期心肌梗死。