Yaghmaei Minoo, Hashemi Mohammad, Shikhzadeh Abdolsamad, Mokhtari Mojgan, Niazi Abbasali, Ghavami Saeid
Department of Obstetrics and Gynecology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Diabetes Res Clin Pract. 2009 Jun;84(3):201-4. doi: 10.1016/j.diabres.2009.03.003. Epub 2009 Apr 2.
Alpha-1-antitrpsin (AAT) is the main antiprotease of plasma. Concentration of serum alpha-1-antitrypsin (AAT) may not be delegate of the functional capacity of this antiprotease. To our knowledge there is not any report regarding the functional level of AAT in gestational diabetes mellitus (GDM). The aim of the present study was to determine serum trypsin inhibitory capacity (sTIC) in gestational diabetes mellitus.
This case-control study was performed in 41 GDM and 40 healthy pregnant women. sTIC was measured by enzymatic assay.
The serum trypsin inhibitory capacity was significantly lower (p<0.001) in GDM (5.84+/-2.27 micromol/min/ml) than healthy pregnant women (7.24+/-1.91 micromol/min/ml).
In gestational diabetes mellitus reduction of serum trypsin inhibitory capacity may be due to non-enzymatic glycosylation of alpha-1-antitrypsin or oxidation of methionin in the active site of alpha-1-antitrypsin which remains to be cleared.
α1-抗胰蛋白酶（AAT）是血浆中的主要抗蛋白酶。血清α1-抗胰蛋白酶（AAT）的浓度可能无法代表这种抗蛋白酶的功能能力。据我们所知，尚无关于妊娠期糖尿病（GDM）中AAT功能水平的报道。本研究的目的是测定妊娠期糖尿病患者的血清胰蛋白酶抑制能力（sTIC）。
本病例对照研究纳入了41例妊娠期糖尿病患者和40例健康孕妇。通过酶法测定sTIC。
妊娠期糖尿病患者的血清胰蛋白酶抑制能力（5.84±2.27微摩尔/分钟/毫升）显著低于健康孕妇（7.24±1.91微摩尔/分钟/毫升）（p<0.001）。
在妊娠期糖尿病中，血清胰蛋白酶抑制能力降低可能是由于α1-抗胰蛋白酶的非酶糖基化或α1-抗胰蛋白酶活性位点中甲硫氨酸的氧化，其原因尚待明确。
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