α-1抗胰蛋白酶在1型和2型糖尿病中的治疗潜力
Therapeutic Potential of Alpha-1 Antitrypsin in Type 1 and Type 2 Diabetes Mellitus.
作者信息
Park Sangmi S, Rodriguez Ortega Romy, Agudelo Christina W, Perez Perez Jessica, Perez Gandara Brais, Garcia-Arcos Itsaso, McCarthy Cormac, Geraghty Patrick
机构信息
Department of Medicine, State University of New York Downstate Health Sciences University, Brooklyn, NY 11203, USA.
University College Dublin School of Medicine, Education and Research Centre, St. Vincent's University Hospital, D04 T6F4 Dublin, Ireland.
出版信息
Medicina (Kaunas). 2021 Apr 20;57(4):397. doi: 10.3390/medicina57040397.
Abstract
Alpha-1 antitrypsin (AAT) has established anti-inflammatory and immunomodulatory effects in chronic obstructive pulmonary disease but there is increasing evidence of its role in other inflammatory and immune-mediated conditions, like diabetes mellitus (DM). AAT activity is altered in both developing and established type 1 diabetes mellitus (T1DM) as well in established type 2 DM (T2DM). Augmentation therapy with AAT appears to favorably impact T1DM development in mice models and to affect β-cell function and inflammation in humans with T1DM. The role of AAT in T2DM is less clear, but AAT activity appears to be reduced in T2DM. This article reviews these associations and emerging therapeutic strategies using AAT to treat DM.
摘要
α-1抗胰蛋白酶（AAT）在慢性阻塞性肺疾病中已被证实具有抗炎和免疫调节作用，但越来越多的证据表明其在其他炎症和免疫介导的疾病中也发挥作用，如糖尿病（DM）。在1型糖尿病（T1DM）的发生发展过程中以及在已确诊的2型糖尿病（T2DM）中，AAT活性均发生改变。在小鼠模型中，AAT增强疗法似乎对T1DM的发展有积极影响，并且对T1DM患者的β细胞功能和炎症有影响。AAT在T2DM中的作用尚不清楚，但T2DM患者的AAT活性似乎有所降低。本文综述了这些关联以及使用AAT治疗糖尿病的新兴治疗策略。
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