School of Medicine and Pharmacology, University of Western Australia, PO Box X2213 GPO, Perth WA 6847, Australia.
Nutr Metab Cardiovasc Dis. 2009 Dec;19(11):774-80. doi: 10.1016/j.numecd.2009.01.003. Epub 2009 Apr 5.
Pre-clinical studies suggest that sesame and its lignans induce beneficial changes in risk factors related to cardiovascular disease and increase the bioavailability of mammalian lignans. However, only very few intervention trials have investigated the potential bioactivities of sesame in humans. We aimed to investigate the effects of sesame supplementation in humans on blood lipids, blood pressure, systemic oxidative stress, inflammatory biomarkers and mammalian lignan metabolism.
We conducted a randomized, placebo-controlled cross-over intervention trial at a university research centre. Overweight or obese men and women (n=33) consumed 25g/d of sesame ( approximately 50mg/d of sesame lignan) and an iso-caloric placebo matched for macronutrient composition for 5 wks each. Each intervention period was preceded by a 4-wk washout period. Blood lipid profiles, day time ambulatory blood pressure, oxidative stress and inflammatory biomarkers and urinary mammalian lignans were measured before and after each intervention. Results are presented as the effect of sesame supplementation relative to placebo. Urinary excretion of the mammalian lignans, enterolactone and enterodiol, increased by approximately 8-fold (P<0.001). Blood lipids and blood pressure were not altered. In addition, markers of systemic inflammation (C-reactive protein, interleukin-6, tumor necrosis factor-alpha) and lipid peroxidation (F(2)-isoprostanes) were not affected.
Supplementation with 25g/d of sesame can significantly increase the exposure to mammalian lignans. However, this did not cause any improvement in markers of cardiovascular disease risk in overweight or obese men and women.
临床前研究表明，芝麻及其木脂素可诱导与心血管疾病相关的风险因素发生有益变化，并提高哺乳动物木脂素的生物利用度。然而，只有极少数干预试验研究了芝麻在人体中的潜在生物活性。我们旨在研究芝麻补充剂对人体血脂、血压、全身氧化应激、炎症生物标志物和哺乳动物木脂素代谢的影响。
我们在大学研究中心进行了一项随机、安慰剂对照交叉干预试验。超重或肥胖的男性和女性（n=33）每天食用 25g 芝麻（约 50mg/d 的芝麻木脂素）和一种与宏量营养素组成相匹配的等热量安慰剂，每种干预持续 5 周，每个干预期之前有 4 周的洗脱期。在每个干预前后测量血脂谱、日间动态血压、氧化应激和炎症生物标志物以及尿中的哺乳动物木脂素。结果以芝麻补充相对于安慰剂的效果呈现。哺乳动物木脂素、肠内酯和肠二醇的尿排泄量增加了约 8 倍（P<0.001）。血脂和血压没有改变。此外，全身炎症标志物（C 反应蛋白、白细胞介素 6、肿瘤坏死因子-α）和脂质过氧化标志物（F2-异前列腺素）也不受影响。
每天补充 25g 芝麻可以显著增加哺乳动物木脂素的暴露量。然而，这并没有改善超重或肥胖男性和女性心血管疾病风险标志物的状况。
