Psychopharmacology Unit, University of Bristol, Bristol, UK.
J Psychopharmacol. 2010 May;24(5):633-8. doi: 10.1177/0269881109103800. Epub 2009 Apr 3.
Although the complimentary roles of heart and brain in anxiety have been recognised for centuries, the precise contribution of each and more importantly perhaps their interplay has proved difficult to describe. Recent data from human brain imaging and cardiovascular physiology studies are beginning to delineate the mechanistic pathways of anxiety disorders in general and panic in particular. Evidence for a dysfunction of brain gamma-amino butyric acid-A and serotonin (5HT) systems in both panic and cardiovascular regulation is reviewed along with new evidence for altered sympathetic nervous system activity in the heart and periphery. Testable hypotheses and research ideas are suggested.
尽管心脑在焦虑中的互补作用已被认识了数个世纪，但每一个的具体贡献，更重要的也许是它们的相互作用，却难以描述。来自人类大脑成像和心血管生理学研究的最新数据开始描绘一般焦虑障碍和惊恐障碍的机制途径。本文回顾了惊恐和心血管调节中脑γ-氨基丁酸-A 和 5-羟色胺（5HT）系统功能障碍的证据，以及心脏和外周交感神经系统活动改变的新证据。提出了可检验的假设和研究思路。
