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霍乱弧菌群体感应系统中的分子多样化：自然选择在大流行菌株出现中的作用。

Molecular diversification in the quorum-sensing system of Vibrio cholerae: Role of natural selection in the emergence of pandemic strains.

作者信息

Talyzina Nina M, Ingvarsson Pär K, Zhu Jun, Wai Sun N, Andersson Agneta

机构信息

Department of Ecology and Environmental Science, Umeå University, Sweden.

出版信息

Appl Environ Microbiol. 2009 Jun;75(11):3808-12. doi: 10.1128/AEM.02496-08. Epub 2009 Apr 3.

DOI:10.1128/AEM.02496-08
PMID:19346342
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2687267/
Abstract

Two haplotypes of the Vibrio cholerae quorum-sensing system regulator hapR are described: hapR1, common among nonpandemic, non-O1, non-O139 strains, and hapR2, associated with pandemic O1 and O139 and epidemic O37 V. cholerae strains. The hapR2 has evolved under strong natural selection, implying that its fixation was influenced by conditions that led to cholera pandemics.

摘要

描述了霍乱弧菌群体感应系统调节因子hapR的两种单倍型：hapR1，在非大流行、非O1、非O139菌株中常见；hapR2，与大流行的O1和O139以及流行的O37霍乱弧菌菌株相关。hapR2在强烈的自然选择下进化，这意味着其固定受到导致霍乱大流行的条件的影响。

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本文引用的文献

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Rapid growth of planktonic Vibrio cholerae non-O1/non-O139 strains in a large alkaline lake in Austria: dependence on temperature and dissolved organic carbon quality.奥地利一个大型碱性湖泊中浮游霍乱弧菌非O1/非O139菌株的快速生长：对温度和溶解有机碳质量的依赖性
Appl Environ Microbiol. 2008 Apr;74(7):2004-15. doi: 10.1128/AEM.01739-07. Epub 2008 Feb 1.
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Serogroup conversion of Vibrio cholerae in aquatic reservoirs.霍乱弧菌在水体储库中的血清型转换
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Genomic and phenotypic diversity of coastal Vibrio cholerae strains is linked to environmental factors.沿海霍乱弧菌菌株的基因组和表型多样性与环境因素有关。
Appl Environ Microbiol. 2007 Jun;73(11):3705-14. doi: 10.1128/AEM.02736-06. Epub 2007 Apr 20.
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Detection and transformation of genome segments that differ within a coastal population of Vibrio cholerae strains.霍乱弧菌菌株沿海群体内不同基因组片段的检测与转化
Appl Environ Microbiol. 2007 Jun;73(11):3695-704. doi: 10.1128/AEM.02735-06. Epub 2007 Apr 20.
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