Talyzina Nina M, Ingvarsson Pär K, Zhu Jun, Wai Sun N, Andersson Agneta
Department of Ecology and Environmental Science, Umeå University, Sweden.
Appl Environ Microbiol. 2009 Jun;75(11):3808-12. doi: 10.1128/AEM.02496-08. Epub 2009 Apr 3.
Two haplotypes of the Vibrio cholerae quorum-sensing system regulator hapR are described: hapR1, common among nonpandemic, non-O1, non-O139 strains, and hapR2, associated with pandemic O1 and O139 and epidemic O37 V. cholerae strains. The hapR2 has evolved under strong natural selection, implying that its fixation was influenced by conditions that led to cholera pandemics.
描述了霍乱弧菌群体感应系统调节因子hapR的两种单倍型:hapR1,在非大流行、非O1、非O139菌株中常见;hapR2,与大流行的O1和O139以及流行的O37霍乱弧菌菌株相关。hapR2在强烈的自然选择下进化,这意味着其固定受到导致霍乱大流行的条件的影响。