Fox Matthew A, Diven Dayna G, Sra Karen, Boretsky Adam, Poonawalla Tasneem, Readinger Allison, Motamedi Massoud, McNichols Roger J
BioTex, Inc., Houston, Texas 77054, USA.
Lasers Surg Med. 2009 Apr;41(4):251-5. doi: 10.1002/lsm.20767.
Previous studies in a hairless Guinea pig model showed that transdermal application of glycerol effected a temporary reduction in dermal scatter of light. This study focuses on the application of this protocol on human patients.
STUDY DESIGN/MATERIALS AND METHODS: After stratum corneal removal, glycerol was applied to human subjects using a low pressure transdermal application device. Optical coherence tomography imaging showed increased intensity of radiation reaching deeper regions in the skin and photographs showed enhanced visualization of dermal structures.
RESULTS/CONCLUSION: Topically applied glycerol increased light penetration of in vivo corneal-stripped skin. This minimally invasive approach to temporary dermal scatter reduction has the potential to improve the efficacy of light-based diagnostic or therapeutic devices.
先前在无毛豚鼠模型中的研究表明，经皮应用甘油可使皮肤光散射暂时降低。本研究聚焦于该方案在人类患者中的应用。
研究设计/材料与方法：去除角质层后，使用低压经皮给药装置将甘油应用于人类受试者。光学相干断层扫描成像显示到达皮肤更深区域的辐射强度增加，照片显示皮肤结构的可视化增强。
结果/结论：局部应用甘油可增加体内去角质皮肤的光穿透性。这种用于暂时减少皮肤散射的微创方法有可能提高基于光的诊断或治疗设备的疗效。
