Channaa H, Surmann P
Institute of Pharmacy, Free University of Berlin, Germany.
Pharmazie. 2009 Mar;64(3):161-5.
The electrochemical behaviour of several N-containing voltammetric active drugs such as 1,4-benzodiazepines (chlordiazepoxide, nitrazepam and diazepam) as well as one nitro-compound (nitrofurantoin) and one azo-compound (phenazopyridine) is described using a new kind of liquid electrode, the hanging galinstan drop electrode. Concentrations of 10(-5) - 10(-8) mol L(-1) are generally measurable. Differential pulse and adsorptive stripping voltammograms are recorded in different supporting electrolytes, like 0.1 M KNO3, acetate buffer solution pH = 4.6 and phosphate buffer solution pH = 7.0. The effects of varying the starting potentials, U(start) for DPV and accumulation times, t(acc) for AdSV are considered. Briefly, it is shown that the novel galinstan electrode is suitable for reducing several functional groups in organic substances, here presented for N-oxide-, azomethine-, nitro- and azo-groups.
使用一种新型液体电极——悬汞镓铟锡滴电极，描述了几种含氮伏安活性药物的电化学行为，这些药物包括1,4 - 苯二氮䓬类（氯氮卓、硝西泮和地西泮）、一种硝基化合物（呋喃妥因）和一种偶氮化合物（非那吡啶）。通常可测量的浓度范围为10(-5) - 10(-8) mol L(-1)。在不同的支持电解质中记录差分脉冲和吸附溶出伏安图，如0.1 M KNO3、pH = 4.6的醋酸盐缓冲溶液和pH = 7.0的磷酸盐缓冲溶液。考虑了改变差分脉冲伏安法的起始电位U(start)和吸附溶出伏安法的积累时间t(acc)的影响。简而言之，结果表明新型汞镓铟锡电极适用于还原有机物质中的几种官能团，本文展示了对N - 氧化物、偶氮甲碱、硝基和偶氮基团的还原。
