与血压正常个体相比，纳曲酮对高血压患者皮肤电疼痛的影响。
Effects of naltrexone on electrocutaneous pain in patients with hypertension compared to normotensive individuals.
作者信息
Ring Christopher, France Christopher R, al'Absi Mustafa, Edwards Louisa, McIntyre David, Carroll Douglas, Martin Una
机构信息
International Centre for Health and Exercise Research, University of Birmingham, Birmingham B15 2TT, UK.
出版信息
Biol Psychol. 2008 Feb;77(2):191-6. doi: 10.1016/j.biopsycho.2007.10.006. Epub 2007 Oct 13.
Abstract
An opioid mechanism may help explain hypertensive hypoalgesia. A double-blind placebo-controlled design compared the effects of opioid blockade (naltrexone) and placebo on electrocutaneous pain threshold, pain tolerance, and retrospective McGill Pain Questionnaire ratings in 35 unmedicated patients with essential hypertension and 28 normotensive individuals. The hypertensives experienced less pain than normotensives during the assessment of their pain tolerance; however, this manifestation of hypertensive hypoalgesia was not moderated by naltrexone. These findings fail to support the hypothesis that essential hypertension is characterised by relative opioid insensitivity.
摘要
阿片类物质机制可能有助于解释高血压性痛觉减退。一项双盲安慰剂对照设计比较了阿片类物质阻断剂（纳曲酮）和安慰剂对35例未用药的原发性高血压患者及28例血压正常个体的皮肤电痛阈、疼痛耐受性和回顾性麦吉尔疼痛问卷评分的影响。在疼痛耐受性评估过程中，高血压患者比血压正常者经历的疼痛更少；然而，纳曲酮并未减轻高血压性痛觉减退的这种表现。这些发现未能支持原发性高血压以相对阿片类物质不敏感为特征这一假说。
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