Morris M C, Taylor J O, Stampfer M J, Rosner B, Sacks F M
Center for Research on Health and Aging, Chicago, IL 60612.
Am J Clin Nutr. 1993 Jan;57(1):59-64. doi: 10.1093/ajcn/57.1.59.
We conducted a double-blind, crossover trial with 18 healthy, untreated mildly hypertensive subjects to test the effect on blood pressure of 6 or 12 g fish oil/d (50% n-3 fatty acids) as compared with an olive oil placebo. Blood pressure was measured every 6 wk in the clinic and three times daily by subjects using a semiautomated device in their homes. Compliance was determined biochemically. No significant changes in home or clinic blood pressure measurements were noted for either dose after 6 or 12 wk of treatment. Clinic blood pressure after 12 g fish oil/d was slightly lower than after placebo treatment by -0.8/-0.4 mm Hg [95% CI: systolic blood pressure (-4.4, +2.8); diastolic blood pressure (-3.2, +2.4)]. Blood pressure changes were not correlated with compliance, baseline dietary fish consumption, or blood pressure. Moderate doses of fish oil did not have a substantial effect on blood pressure. We conclude that fish oil is not a practical treatment for mild hypertension.
我们对18名健康、未经治疗的轻度高血压受试者进行了一项双盲交叉试验，以测试每天服用6克或12克鱼油（50%为n-3脂肪酸）与橄榄油安慰剂相比对血压的影响。在诊所每6周测量一次血压，受试者在家中使用半自动设备每天测量三次血压。通过生化方法确定依从性。治疗6周或12周后，两种剂量的鱼油对家庭或诊所血压测量值均无显著变化。每天服用12克鱼油后的诊所血压比安慰剂治疗后略低-0.8/-0.4毫米汞柱[95%置信区间：收缩压（-4.4，+2.8）；舒张压（-3.2，+2.4）]。血压变化与依从性、基线饮食中鱼类摄入量或血压无关。中等剂量的鱼油对血压没有实质性影响。我们得出结论，鱼油不是轻度高血压的实用治疗方法。
