Menichini Federica, Tundis Rosa, Loizzo Monica R, Bonesi Marco, Marrelli Mariangela, Statti Giancarlo A, Menichini Francesco, Conforti Filomena
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria, Italy.
Fitoterapia. 2009 Jul;80(5):297-300. doi: 10.1016/j.fitote.2009.03.008. Epub 2009 Apr 5.
Ethanolic extract from the fruits of Pimpinella anisoides, an aromatic plant and a spice, exhibited activity against AChE and BChE, with IC(50) values of 227.5 and 362.1 microg/ml, respectively. The most abundant constituents of the extract were trans-anethole, (+)-limonene and (+)-sabinene. trans-Anethole exhibited the highest activity against AChE and BChE with IC(50) values of 134.7 and 209.6 microg/ml, respectively. The bicyclic monoterpene (+)-sabinene exhibited a promising activity against AChE (IC(50) of 176.5 microg/ml) and BChE (IC(50) of 218.6 microg/ml).
茴芹属植物（一种芳香植物和香料）果实的乙醇提取物对乙酰胆碱酯酶（AChE）和丁酰胆碱酯酶（BChE）具有活性，其半数抑制浓度（IC50）值分别为227.5和362.1微克/毫升。提取物中含量最丰富的成分是反式茴香脑、（+）-柠檬烯和（+）-桧烯。反式茴香脑对AChE和BChE表现出最高活性，IC50值分别为134.7和209.6微克/毫升。双环单萜（+）-桧烯对AChE（IC50为176.5微克/毫升）和BChE（IC50为218.6微克/毫升）表现出有前景的活性。
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